General Information of DTT (ID: TTN9VTF)

DTT Name Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DTT Info
Gene Name SCN11A

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
8 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [1]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [2]
Lacosamide DMVM6QR Convulsion 8A68.Z Approved [1]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [3]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [4]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [5]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [6]
Tolperisone DMA2GHJ Muscle spasm MB47.3 Approved [7]
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⏷ Show the Full List of 8 Approved Drug(s)
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
HP-184 DMNOMV2 Multiple sclerosis 8A40 Phase 2 [8]
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1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
QX-314 DMAV2FM Pain MG30-MG3Z Terminated [9]
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2 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
PD-32577 DMBA15J Discovery agent N.A. Investigative [10]
SB-221420-A DMMWCLV Pain MG30-MG3Z Investigative [11]
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Molecule Interaction Atlas

References

1 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2 New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
3 The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9.
4 Mechanisms of analgesia of intravenous lidocaine. Rev Bras Anestesiol. 2008 May-Jun;58(3):280-6.
5 Debate: Does genetic information in humans help us treat patients PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all. Epilepsia. 2008 Dec;49 Suppl 9:13-24.
6 Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res. 2002;137:177-90.
7 Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46.
8 Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
9 Voltage-gated sodium channel blockers for the treatment of chronic pain. Curr Top Med Chem. 2009;9(4):362-76.
10 Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.
11 Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95.