Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNYZG2)

• DTT Name: Granulocyte-macrophage colony-stimulating factor (CSF2) DTT Info
• Gene Name: CSF2

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talimogene Laherparepvec	DMKBW5C	Melanoma	2C30	Approved	[1]

11 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JX-594	DM5WCV4	Hepatocellular carcinoma	2C12.02	Phase 3	[2]
Cabiralizumab	DMGE058	Pancreatic cancer	2C10	Phase 2	[3]
GSK3196165	DMEXKF4	Rheumatoid arthritis	FA20	Phase 2	[4]
KB-003	DM74KIM	Severe asthma	CA23	Phase 2	[5]
KB002/003	DM60G5O	Rheumatoid arthritis	FA20	Phase 2	[6]
Mavrilimumab	DMMVFRC	Rheumatoid arthritis	FA20	Phase 2	[4]
MT203	DM7I0MT	Plaque psoriasis	EA90.0	Phase 2	[7]
Autologous melanoma cell vaccine	DMARYFK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
CDNA vaccine	DM8DWOL	Prostate cancer	2C82.0	Phase 1	[6]
CGTG-102	DMAY8I4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
MORAb-022	DMM7TBO	Autoimmune diabetes	5A10	Phase 1	[9]

1 Drugs in Phase 3 Trial Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenzilumab	DMSRIT4	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3 Trial	[3]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RPK-739	DMUCP8K	Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
human monoclonal antibodies (GM-CSF)	DMFV5UL	Discovery agent	N.A.	Investigative	[10]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF. Mol Ther. 2006 Sep;14(3):361-70.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast.
• [6] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [7] GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential. Expert Rev Clin Immunol. 2015 Apr;11(4):457-65.
• [8] Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans. Int J Cancer. 2014 Aug 1;135(3):720-30.
• [9] Clinical pipeline report, company report or official report of Morphotek.
• [10] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.