Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTOA6YT)

• DTT Name: MERS-CoV RNA-directed RNA polymerase (RdRp) DTT Info
• Gene Name: MERS-CoV rep

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[1]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[2]

1 Drugs in Phase 1 Trial Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Galidesivir	DMG9C4I	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1 Trial	[2]

2 Preclinical Drugs Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26048809-compound2	DMFNS7U	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[2]
PMID31244113-compound-2c	DMZJWON	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[3]

1 Investigative Agents Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amarylline	DML9W2V	Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[4]

References

• [1] Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 Jan 10;11(1):222.
• [2] Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
• [3] Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem. 2019 Jul 11;62(13):6346-6362.
• [4] Lycorine: A prospective natural lead for anticancer drug discovery. Biomed Pharmacother. 2018 Nov;107:615-624.