Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTOI92F)

• DTT Name: Multidrug resistance-associated protein 1 (ABCC1) DTT Info
• Gene Name: ABCC1

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[1]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[2]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrrolopyrimidine	DMZLFVG	Discovery agent	N.A.	Investigative	[3]
XR-9456	DMTUFI1	Discovery agent	N.A.	Investigative	[4]
XR-9504	DMIQP69	Discovery agent	N.A.	Investigative	[4]
XR-9544	DM1OZPN	Discovery agent	N.A.	Investigative	[4]
XR-9577	DMIZV6T	Discovery agent	N.A.	Investigative	[4]

References

• [1] Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transpo... Drug Metab Dispos. 2009 Jan;37(1):129-36.
• [2] Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2). Drug Metab Dispos. 2008 Apr;36(4):631-40.
• [3] Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4967-72.
• [4] Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62.