Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQ38E9)

• DTT Name: Sodium/potassium-transporting ATPase (SPT ATPase) DTT Info
• Gene Name: ATP1A1

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Digitoxin	DMWVIGP	Arrhythmia	BC9Z	Approved	[1]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[2]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[3]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[4]
Rostafuroxin	DMKQXDB	Hypertension	BA00-BA04	Phase 2	[5]
RX108	DM4XETK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Istaroxime	DMWN09H	Cardiac disease	BA00-BE2Z	Discontinued in Phase 2	[7]
Cordil	DMQESM7	Heart arrhythmia	BC65	Terminated	[8]

References

• [1] Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7.
• [2] Fab antibody fragments: some applications in clinical toxicology. Drug Saf. 2004;27(14):1115-33.
• [3] Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81.
• [4] First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf- beta and p70s6k, in patients with advanced solid tumors. Invest New Drugs. 2014 Dec;32(6):1204-12.
• [5] Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35.
• [6] ClinicalTrials.gov (NCT03646071) A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
• [7] Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8.
• [8] WO patent application no. 1995,0085,58, Novel deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds.