Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQHAXM)

• DTT Name: Peptidyl arginine deiminase type IV (PADI4) DTT Info
• Gene Name: PADI4

Molecule-Related Drug & Molecule List

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cl-amidine	DMRV89X	Discovery agent	N.A.	Investigative	[1]
PMID24440480C3	DMHQK54	Discovery agent	N.A.	Investigative	[2]
PMID25742366C14b	DMDYT6P	Discovery agent	N.A.	Investigative	[1]
streptonigrin	DM0HOEA	Discovery agent	N.A.	Investigative	[3]

References

• [1] Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21.
• [2] Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.
• [3] A fluopol-ABPP HTS assay to identify PAD inhibitors. Chem Commun (Camb). 2010 Oct 14;46(38):7175-7.