Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTR1D7X)

• DTT Name: Protein arginine methyltransferase 5 (PRMT5) DTT Info
• Gene Name: PRMT5

Molecule-Related Drug & Molecule List

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 193	DMU9K8N	Aggressive cancer	2A00-2F9Z	Phase 2	[1]
GSK3326595	DMJRD7A	Breast cancer	2C60-2C65	Phase 2	[2]
JNJ-64619178	DMDBW2N	Myelodysplastic syndrome	2A37	Phase 1	[3]
PF-06939999	DM7BOFR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
PRT543	DMHNZ3U	Hematologic tumour	2B33.Y	Phase 1	[5]
PRT811	DMW3MCX	Glioma	2A00.0	Phase 1	[6]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
cmp5	DMBT2ZW	Discovery agent	N.A.	Investigative	[7]
DS-437	DME3WBQ	Discovery agent	N.A.	Investigative	[8]
EPZ015666	DM3INX7	Discovery agent	N.A.	Investigative	[9]

References

• [1] AMG 193 Effective in Multiple Tumor Types. Cancer Discov. 2023 Dec 12;13(12):2492.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] A patent review of arginine methyltransferase inhibitors (2010-2018). Expert Opin Ther Pat. 2019 Feb;29(2):97-114.
• [4] National Cancer Institute Drug Dictionary (drug name PF-06939999).
• [5] Clinical pipeline report, company report or official report of Prelude Therapeutics.
• [6] Clinical pipeline report, company report or official report of Prelude Therapeutics.
• [7] Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015 Apr 16;125(16):2530-43.
• [8] Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12.
• [9] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1256).