General Information of DTT (ID: TTRFOXJ)

DTT Name Protein kinase C gamma (PRKCG) DTT Info
Gene Name PRKCG

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [1]
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3 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [2]
LY-317644 DMM20PI N. A. N. A. Terminated [3]
RO-320432 DMFZ1YW N. A. N. A. Terminated [4]
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25 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(-)-Cercosporamide DMJ249P Discovery agent N.A. Investigative [5]
2,3,3-Triphenyl-acrylonitrile DM7H34U Discovery agent N.A. Investigative [6]
2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A Discovery agent N.A. Investigative [6]
3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG Discovery agent N.A. Investigative [6]
3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 Discovery agent N.A. Investigative [6]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [7]
3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT Discovery agent N.A. Investigative [7]
3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 Discovery agent N.A. Investigative [6]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [7]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [7]
4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC Discovery agent N.A. Investigative [6]
4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 Discovery agent N.A. Investigative [6]
4-cyclopentyliden(4-hydroxyphenyl)methylphenol DM7LN53 Discovery agent N.A. Investigative [6]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 Discovery agent N.A. Investigative [6]
8-Octyl-benzolactam-V9 DM4Z15M Discovery agent N.A. Investigative [8]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [9]
Go 6983 DMKVTZN Discovery agent N.A. Investigative [10]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [11]
Monoctanoin component C DM31YGM Discovery agent N.A. Investigative [12]
PROSTRATIN DM1HMJ5 Human immunodeficiency virus infection 1C62 Investigative [13]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [14]
Ro-32-0557 DMPVKEA Discovery agent N.A. Investigative [4]
[2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F Discovery agent N.A. Investigative [15]
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI Discovery agent N.A. Investigative [15]
[2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ Discovery agent N.A. Investigative [15]
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⏷ Show the Full List of 25 Investigative Drug(s)
Molecule Interaction Atlas

References

1 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
2 Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
3 Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995).
4 Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).
5 (-)-Cercosporamide derivatives as novel antihyperglycemic agents. Bioorg Med Chem Lett. 2009 Feb 1;19(3):724-6.
6 Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83.
7 Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81.
8 Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
9 Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63.
10 Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80.
11 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
12 Synthesis and characterization of the second cysteine-rich region of mouse skin PKCGh, Bioorg. Med. Chem. Lett. 6(4):353-356 (1996).
13 A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
14 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
15 Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.