Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTRICUF)

• DTT Name: Interleukin-18 (IL18) DTT Info
• Gene Name: IL18

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tadekinig alfa	DM1NTVQ	XIAP deficiency	4A01.22	Phase 3	[1]
GSK-1070806	DMQGPLO	Type-2 diabetes	5A11	Phase 2	[2]
Iboctadekin	DMHS29U	Non-hodgkin lymphoma	2B33.5	Phase 1	[3]
MEDI-2338	DMCMYPX	Chronic obstructive pulmonary disease	CA22	Phase 1	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IL-18BP	DMRSJ49	B-cell non-hodgkin lymphoma	2B33.5	Discontinued in Phase 1	[5]

References

• [1] Clinical pipeline report, company report or official report of AB2 Bio.
• [2] Targeting the IL-1 family members in skin inflammation. Curr Opin Investig Drugs. 2010 November; 11(11): 1211-1220.
• [3] Chemoimmunotherapy using pegylated liposomal Doxorubicin and interleukin-18 in recurrent ovarian cancer: a phase I dose-escalation study. Cancer Immunol Res. 2013 Sep;1(3):168-78.
• [4] Cytokine inhibition in the treatment of COPD. Int J Chron Obstruct Pulmon Dis. 2014; 9: 397-412.
• [5] Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.