Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSHTOI)

• DTT Name: Histone deacetylase 2 (HDAC2) DTT Info
• UniProt ID: HDAC2_HUMAN
• Gene Name: HDAC2

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CHR-3996	DMIXPNG	Lymphoma	2A80-2A86	Phase 1/2	[1]

16 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29671355-Compound-11	DMNKABH	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-44	DM80A3V	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-55	DMJV1SY	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-59	DM2F0CQ	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-61	DMXH1G3	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-74	DM49YTU	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-8	DM7YQJK	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-9	DMXL96M	N. A.	N. A.	Patented	[2]

96 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one	DM5LSY9	Discovery agent	N.A.	Investigative	[3]
1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one	DM6GI4Z	Discovery agent	N.A.	Investigative	[4]
1,1,1-Trifluoro-8-phenoxy-octan-2-one	DM41R2O	Discovery agent	N.A.	Investigative	[4]
2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide	DM6P20R	Discovery agent	N.A.	Investigative	[5]
2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide	DM48C7G	Discovery agent	N.A.	Investigative	[5]
2-(methylsulfonylthio)ethyl 2-propylpentanoate	DMM52D3	Discovery agent	N.A.	Investigative	[6]
4-Benzoylamino-N-hydroxy-benzamide	DMYBPFS	Discovery agent	N.A.	Investigative	[7]
4-Butyrylamino-N-hydroxy-benzamide	DMRY6B4	Discovery agent	N.A.	Investigative	[8]
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide	DM5AVG3	Discovery agent	N.A.	Investigative	[9]
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide	DM0M8G5	Discovery agent	N.A.	Investigative	[10]
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide	DMULOHZ	Discovery agent	N.A.	Investigative	[11]
4-Phenylbutyrohydroxamic acid	DMCZKN7	Discovery agent	N.A.	Investigative	[12]
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide	DM6CRVS	Discovery agent	N.A.	Investigative	[13]
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione	DM7KQXL	Discovery agent	N.A.	Investigative	[6]
5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide	DMPQSZN	Discovery agent	N.A.	Investigative	[14]
5-Mercapto-pentanoic acid phenylamide	DMET3OJ	Discovery agent	N.A.	Investigative	[10]
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide	DM9LKXD	Discovery agent	N.A.	Investigative	[10]
6-benzenesulfinylhexanoic acid hydroxamide	DM2I95Z	Discovery agent	N.A.	Investigative	[15]
6-benzenesulfonylhexanoic acid hydroxamide	DMY9IK8	Discovery agent	N.A.	Investigative	[15]
6-Mercapto-hexanoic acid phenylamide	DMD2FW9	Discovery agent	N.A.	Investigative	[10]
6-Phenoxy-hexane-1-thiol	DMVYIN2	Discovery agent	N.A.	Investigative	[10]
6-phenylsulfanylhexanoic acid hydroxamide	DM3OLM6	Discovery agent	N.A.	Investigative	[15]
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one	DMLCGSY	Discovery agent	N.A.	Investigative	[3]
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one	DM28GZ7	Discovery agent	N.A.	Investigative	[4]
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one	DMY027P	Discovery agent	N.A.	Investigative	[3]
7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide	DMO4YLA	Discovery agent	N.A.	Investigative	[16]
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one	DM4VQN8	Discovery agent	N.A.	Investigative	[3]
7-Biphenyl-4-yl-heptanoic acid hydroxyamide	DMV54MT	Discovery agent	N.A.	Investigative	[17]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide	DMPYTHV	Discovery agent	N.A.	Investigative	[10]
7-Mercapto-heptanoic acid biphenyl-3-ylamide	DMEQKPO	Discovery agent	N.A.	Investigative	[10]
7-Mercapto-heptanoic acid biphenyl-4-ylamide	DMJMOUK	Discovery agent	N.A.	Investigative	[10]
7-Mercapto-heptanoic acid phenylamide	DM4912P	Discovery agent	N.A.	Investigative	[10]
7-Mercapto-heptanoic acid pyridin-3-ylamide	DMQ9PLA	Discovery agent	N.A.	Investigative	[10]
7-Mercapto-heptanoic acid quinolin-3-ylamide	DMTAGJ1	Discovery agent	N.A.	Investigative	[10]
7-Phenoxy-heptanoic acid hydroxyamide	DM1FL5G	Discovery agent	N.A.	Investigative	[17]
8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one	DMH3SDO	Discovery agent	N.A.	Investigative	[4]
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one	DM23XGW	Discovery agent	N.A.	Investigative	[4]
8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid	DMDIGPW	Discovery agent	N.A.	Investigative	[16]
8-Mercapto-octanoic acid phenylamide	DMD3FWU	Discovery agent	N.A.	Investigative	[10]
8-Oxo-8-phenyl-octanoic acid	DMXDQ25	Discovery agent	N.A.	Investigative	[11]
8-Oxo-8-phenyl-octanoic acid hydroxyamide	DMWM1UL	Discovery agent	N.A.	Investigative	[9]
8-Phenyl-octanoic acid hydroxyamide	DM516NE	Discovery agent	N.A.	Investigative	[17]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide	DMVBCID	Discovery agent	N.A.	Investigative	[4]
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one	DMIY3D6	Discovery agent	N.A.	Investigative	[4]
Cyclostellettamine derivative	DMFTDPQ	Discovery agent	N.A.	Investigative	[18]
KAR-1880	DMXAK75	Dermatitis	EA80-EA89	Investigative	[19]
N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide	DM7VN9P	Discovery agent	N.A.	Investigative	[20]
N-(2-amino-5-(furan-2-yl)phenyl)benzamide	DMY9HO8	Discovery agent	N.A.	Investigative	[20]
N-(2-amino-5-(furan-3-yl)phenyl)benzamide	DMI7W9N	Discovery agent	N.A.	Investigative	[20]
N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide	DM1KVPG	Discovery agent	N.A.	Investigative	[20]
N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide	DM2K0AJ	Discovery agent	N.A.	Investigative	[20]
N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide	DMFYG79	Discovery agent	N.A.	Investigative	[21]
N-(2-aminophenyl)-4-methoxybenzamide	DMTKWUM	Discovery agent	N.A.	Investigative	[22]
N-(2-aminophenyl)benzamide	DM8PB90	Discovery agent	N.A.	Investigative	[20]
N-(2-aminophenyl)nicotinamide	DMRDQ1B	Discovery agent	N.A.	Investigative	[21]
N-(2-aminophenyl)quinoxaline-6-carboxamide	DMJXV7C	Discovery agent	N.A.	Investigative	[22]
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide	DM0GOPV	Discovery agent	N.A.	Investigative	[23]
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide	DMJLFOQ	Discovery agent	N.A.	Investigative	[23]
N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide	DMYJB1A	Discovery agent	N.A.	Investigative	[20]
N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide	DMIJLX6	Discovery agent	N.A.	Investigative	[20]
N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide	DMV6154	Discovery agent	N.A.	Investigative	[20]
N-(4-amino-3'-methylbiphenyl-3-yl)benzamide	DM910BF	Discovery agent	N.A.	Investigative	[20]
N-(4-amino-4'-bromobiphenyl-3-yl)benzamide	DMIAGS8	Discovery agent	N.A.	Investigative	[20]
N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide	DMR5D16	Discovery agent	N.A.	Investigative	[20]
N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide	DM93PDA	Discovery agent	N.A.	Investigative	[20]
N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide	DMSUJDH	Discovery agent	N.A.	Investigative	[20]
N-(4-aminobiphenyl-3-yl)benzamide	DMLA92O	Discovery agent	N.A.	Investigative	[20]
N-(4-aminobiphenyl-3-yl)nicotinamide	DMXVZIY	Discovery agent	N.A.	Investigative	[21]
N-(4-hydroxybiphenyl-3-yl)benzamide	DMC5H8G	Discovery agent	N.A.	Investigative	[21]
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide	DMSUW7M	Discovery agent	N.A.	Investigative	[9]
N-(6-Hydroxycarbamoyl-hexyl)-benzamide	DMIZVMT	Discovery agent	N.A.	Investigative	[11]
N-(6-Mercapto-hexyl)-benzamide	DM01Y37	Discovery agent	N.A.	Investigative	[10]
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide	DMCN91A	Discovery agent	N.A.	Investigative	[7]
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide	DMVK2Y3	Discovery agent	N.A.	Investigative	[7]
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide	DMHEQ41	Discovery agent	N.A.	Investigative	[7]
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide	DMUOCQB	Discovery agent	N.A.	Investigative	[24]
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide	DMVEOBY	Discovery agent	N.A.	Investigative	[7]
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide	DMISRMT	Discovery agent	N.A.	Investigative	[7]
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide	DMGTNQY	Discovery agent	N.A.	Investigative	[8]
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide	DMDUOH4	Discovery agent	N.A.	Investigative	[8]
N-Hydroxy-4-phenylacetylamino-benzamide	DMCRU17	Discovery agent	N.A.	Investigative	[7]
N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide	DM3J5MR	Discovery agent	N.A.	Investigative	[14]
N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide	DMVFKO4	Discovery agent	N.A.	Investigative	[14]
N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide	DMQCK5G	Discovery agent	N.A.	Investigative	[14]
N7-hydroxy-2-methoxy-N1-phenylheptanediamide	DM6XDZA	Discovery agent	N.A.	Investigative	[5]
N7-hydroxy-N1-phenyl-2-propoxyheptanediamide	DMDJUZX	Discovery agent	N.A.	Investigative	[5]
N8,2-dihydroxy-N1-phenyloctanediamide	DMHC32M	Discovery agent	N.A.	Investigative	[5]
N8-hydroxy-2-methoxy-N1-phenyloctanediamide	DM7OZ2T	Discovery agent	N.A.	Investigative	[5]
Octanedioic acid bis-hydroxyamide	DMJNQ9K	Discovery agent	N.A.	Investigative	[25]
Octanedioic acid hydroxyamide pyridin-2-ylamide	DMHNWS1	Discovery agent	N.A.	Investigative	[11]
Octanedioic acid hydroxyamide pyridin-4-ylamide	DM945RK	Discovery agent	N.A.	Investigative	[11]
PSAMMAPLIN A	DM6T0IQ	Discovery agent	N.A.	Investigative	[9]
santacruzamate A	DMFAM7P	Discovery agent	N.A.	Investigative	[26]
ST-2986	DMNERM6	Discovery agent	N.A.	Investigative	[27]
ST-2987	DMWXTM8	Solid tumour/cancer	2A00-2F9Z	Investigative	[27]
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester	DMBOKSF	Discovery agent	N.A.	Investigative	[10]

References

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• [2] HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17.
• [3] Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13.
• [4] Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7.
• [5] Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5.
• [6] New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7.
• [7] Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5.
• [8] Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74.
• [9] Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116.
• [10] Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32.
• [11] Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7.
• [12] Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243.
• [13] Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.
• [14] Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12.
• [15] Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5.
• [16] Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5.
• [17] A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20.
• [18] Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.
• [19] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2616).
• [20] Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5.
• [21] Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).
• [22] Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6.
• [23] Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72.
• [24] Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetyla... Eur J Med Chem. 2009 Nov;44(11):4470-6.
• [25] Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differenti... J Med Chem. 2002 Jul 18;45(15):3296-309.
• [26] Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33.
• [27] N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9.