Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTT3IXG)

• DTT Name: Kynurenine oxoglutarate transaminase II (AADAT) DTT Info
• Gene Name: AADAT

Molecule-Related Drug & Molecule List

7 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US10065972, Example 281	DMBWJK4	N. A.	N. A.	Patented	[1]
US10065972, Example 396	DMT8WVZ	N. A.	N. A.	Patented	[1]
US10065972, Example 560	DM9QCTJ	N. A.	N. A.	Patented	[1]
US8933095, 1	DMG3T7E	N. A.	N. A.	Patented	[2]
US8933095, 14	DMZUNJ4	N. A.	N. A.	Patented	[3]
US8933095, 16	DMRN5F4	N. A.	N. A.	Patented	[2]
US8933095, 18	DMOZ4FS	N. A.	N. A.	Patented	[3]

3 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-4-(Ethylsulfonyl)benzoylalanine	DMEJYV4	Cognitive impairment	6D71	Preclinical	[4]
BFF-122	DM6BGJ9	Cognitive impairment	6D71	Preclinical	[5]
PF-04859989	DM3U2S5	Cognitive impairment	6D71	Preclinical	[6]

References

• [1] Bicyclic or tricyclic heterocyclic compound. US10065972.
• [2] KAT II inhibitors. US8933095.
• [3] KAT II inhibitors. US8598200.
• [4] Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 2009 Mar 3;159(1):196-203.
• [5] Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
• [6] Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations. Brain Res Bull. 2019 Mar;146:185-191.