Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTT3YKH)

• DTT Name: Somatotropin (GH1) DTT Info
• Gene Name: GH1

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lonapegsomatropin	DMPR8E9	Growth failure	LD2F.1Y	Approved	[1]

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Albutropin	DMWAL73	Growth failure	LD2F.1Y	Phase 3	[2]
HGH-CTP	DMXAZ47	Growth hormone deficiency	5A61.3	Phase 3	[3]
VRS-317	DMWMT5N	Growth hormone deficiency	5A61.3	Phase 3	[4]
Somatropin intranasal rhGH	DMK3RL8	Growth hormone deficiency	5A61.3	Phase 2	[5]
YPEG-Somatropin	DMCM0K6	Growth hormone deficiency	5A61.3	Phase 1	[6]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARX-201	DMS0LCZ	Growth failure	LD2F.1Y	Discontinued in Phase 2	[7]

References

• [1] ClinicalTrials.gov (NCT01947907) Safety, PK/PD and Efficacy of ACP-001 Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD). U.S. National Institutes of Health.
• [2] Albutropin: a growth hormone-albumin fusion with improved pharmacokinetics and pharmacodynamics in rats and monkeys. Eur J Pharmacol. 2002 Dec 5;456(1-3):149-58.
• [3] Developments in human growth hormone preparations: sustained-release, prolonged half-life, novel injection devices, and alternative delivery routes. Int J Nanomedicine. 2014; 9: 3527-3538.
• [4] Company report (Versartis)
• [5] Long-term efficacy and safety of somatropin for adult growth hormone deficiency.Treat Endocrinol.2003;2(2):109-20.
• [6] Somatropin therapy in adults with Prader-Willi syndrome. Treat Endocrinol. 2004;3(3):153-60.
• [7] Company report (Avarx)