Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTTDVOJ)

• DTT Name: Tropomyosin-related kinase A (TrkA) DTT Info
• UniProt ID: NTRK1_HUMAN
• Gene Name: NTRK1

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Entrectinib	DMMPTLH	Non-small cell lung cancer	2C25	Approved	[1]
Larotrectinib	DM26CQR	Solid tumour/cancer	2A00-2F9Z	Approved	[2], [3]

10 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MIM-D3	DMZHN5B	Alzheimer disease	8A20	Phase 3	[4]
CT 327	DMQXL1T	Plaque psoriasis	EA90.0	Phase 2	[5]
SNA-120	DMPN314	Plaque psoriasis	EA90.0	Phase 2	[6]
ONO-7579	DMXLPYE	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[7]
TPX-0005	DM9FB2T	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[7]
Altiratinib	DMUJCBT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
DS-6051	DM0RD4F	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
LOXO-195	DMDXFBJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
PLX7486	DM0IVGU	Pancreatic cancer	2C10	Phase 1	[10], [7]
VMD-928	DM4AXPT	Lymphoma	2A80-2A86	Phase 1	[11]

121 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-amino-5-benzyl-substituted indazole derivative 1	DMFDURZ	Chronic pain	MG30	Patented	[12]
Azaindazole amide derivative 1	DMJWH4B	Chronic pain	MG30	Patented	[12]
Benzimidazole derivative 6	DMV7TMB	Solid tumour/cancer	2A00-2F9Z	Patented	[8]
Bicyclic heteroaryl benzamide derivative 1	DMTBWC9	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 2	DM5MT4R	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 3	DM54EV2	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 4	DMUBDYG	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 5	DMFOVPT	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 6	DMQGYWV	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 7	DMM1LKF	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 8	DMVBQJ1	Chronic pain	MG30	Patented	[12]
Bicyclic heteroaryl benzamide derivative 9	DMGONY4	Chronic pain	MG30	Patented	[12]
Five membered heterocyclic benzamide derivative 1	DMPFAST	Chronic pain	MG30	Patented	[12]
Five membered heterocyclic benzamide derivative 2	DM4U63E	Chronic pain	MG30	Patented	[12]
Five membered heterocyclic benzamide derivative 3	DMUS4Z0	Chronic pain	MG30	Patented	[12]
Imidazo pyridine derivative 1	DMCXHGW	Chronic pain	MG30	Patented	[12]
Imidazo[1,2-b]pyridazine derivative 1	DMULTAI	Solid tumour/cancer	2A00-2F9Z	Patented	[8]
Imidazo[1,2-b]pyridazine derivative 2	DM1JYNW	Solid tumour/cancer	2A00-2F9Z	Patented	[8]
Imidazo[1,2-b]pyridazine derivative 3	DMPDTG0	Solid tumour/cancer	2A00-2F9Z	Patented	[8]
Imidazo[1,2-b]pyridazine derivative 4	DM2DL4I	N. A.	N. A.	Patented	[8]
Imidazo[1,2-b]pyridazine derivative 5	DMK8V7A	N. A.	N. A.	Patented	[8]
Imidazo[1,2-b]pyridazine derivative 6	DMSIRC2	N. A.	N. A.	Patented	[8]
Imidazo[1,2-b]pyridazine derivative 7	DMDQLUP	N. A.	N. A.	Patented	[8]
N,N-bis(5-pyrazoyl)urea derivative 1	DMSD4G0	N. A.	N. A.	Patented	[8]
N-(phenylpyrazolyl)benzamide derivative 1	DM0ZJX7	Chronic pain	MG30	Patented	[12]
N-acylpiperidine ether derivative 1	DM5GCUR	Chronic pain	MG30	Patented	[12]
N-acylpiperidine ether derivative 2	DM02RQ4	Chronic pain	MG30	Patented	[12]
N-acylpiperidine ether derivative 3	DMXWE5R	Chronic pain	MG30	Patented	[12]
N-acylpiperidine ether derivative 4	DMBUQDR	Chronic pain	MG30	Patented	[12]
N-acylpiperidine ether derivative 5	DMQ2MKT	Chronic pain	MG30	Patented	[12]
N-acylpiperidine ether derivative 6	DMAS01P	Chronic pain	MG30	Patented	[12]
N-acylpiperidine ether derivative 7	DMCJR4N	Chronic pain	MG30	Patented	[12]
N-acylpyrrolidine ether derivative 1	DMQ4ULC	Chronic pain	MG30	Patented	[12]
N-acylpyrrolidine ether derivative 2	DMK4Y71	Chronic pain	MG30	Patented	[12]
N-arylmethyl-N-phenyl cyclic urea derivative 1	DMQHAU1	N. A.	N. A.	Patented	[8]
N-arylmethyl-N-phenyl cyclic urea derivative 2	DMWVQDA	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure16-a	DMBHRUP	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure16-b-1	DMAIRL2	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure16-b-2	DM6YLMB	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure17-1	DMPOI27	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure17-2	DM7QLX8	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure17-3	DME0TUJ	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure24-a	DMNTQL5	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure24-b	DM0QHLK	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure5-1	DM2YAPJ	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure5-2	DMK3GRZ	N. A.	N. A.	Patented	[8]
PMID28270010-Compound-Figure5-3	DMSOT1R	N. A.	N. A.	Patented	[8]
PMID28270021-Compound-WO2010077680 103	DM437ZC	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2010077680 109	DMNUA21	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2010077680 201	DMQAZMC	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2010077680 481	DM6VAS2	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2010077680 495	DMQ9CBS	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2010077680 803	DM6TJU0	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2010077680 811	DM47FNS	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2013009582Example16	DMVS7CJ	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2013009582Example76	DMQK4IX	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2013161919Example85-117	DM2XKTB	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2014078408Example1	DMO02EL	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2014078408Example26	DMVCBSK	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2014129431Example8-1	DMKO4ZH	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2014152663 701	DMA04P6	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2015042088Example11	DM16URY	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2015042088Example12	DMOZHGU	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2015042088Example4	DM6KXOQ	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2016054807Example1	DMD5QEL	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2016054807Example112	DMW2ZRM	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2016054807Example71	DMREZ9I	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2016054807Example80	DMPI86D	Chronic pain	MG30	Patented	[12]
PMID28270021-Compound-WO2016054807Example82	DM9ADSN	Chronic pain	MG30	Patented	[12]
Pyrazolo[1,5-a]pyridine derivative 1	DMH1W89	Chronic pain	MG30	Patented	[12]
Pyrazolo[1,5-a]pyridine derivative 2	DMLS827	Chronic pain	MG30	Patented	[12]
Pyrazolo[1,5-a]pyrimidine derivative 14	DMB6EFV	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 15	DMAZI3D	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 16	DMTYN2D	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 17	DMNIER3	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 18	DMVEP6Y	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 19	DMFV36A	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 20	DMJLU8R	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 21	DMWNZTI	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 22	DMG5CXB	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 23	DMQVLP8	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 24	DMT4ZP9	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 25	DMKE7YO	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 26	DMGZ59Q	N. A.	N. A.	Patented	[8]
Pyrazolo[1,5-a]pyrimidine derivative 27	DM9OXAB	N. A.	N. A.	Patented	[8]
Pyrazolo[4,3-c]pyridine derivative 1	DMHRUIZ	Chronic pain	MG30	Patented	[12]
Pyrazolo[4,3-h]quinazoline-3-carboxamide derivative 1	DMTM82B	Chronic pain	MG30	Patented	[12]
Pyrido[3,2-d]pyrimidine derivative 2	DMRHAU4	Chronic pain	MG30	Patented	[12]
Pyrido[3,2-d]pyrimidine derivative 3	DM6D1XR	Chronic pain	MG30	Patented	[12]
Pyrrolidinyl urea derivative 10	DMV6YXJ	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 11	DMWKSF3	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 12	DMJ6IE5	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 13	DM3VL82	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 2	DMYFP95	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 3	DMFDLHN	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 4	DM8SZKU	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 5	DMU51T4	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 6	DM01GEB	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 7	DMYADJP	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 8	DMW2JG8	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 9	DMO1I4W	N. A.	N. A.	Patented	[8]
Pyrrolo[2,3-b]pyridine derivative 1	DMVKCQU	Chronic pain	MG30	Patented	[12]
Pyrrolo[2,3-b]pyridine derivative 2	DM7IPWB	Chronic pain	MG30	Patented	[12]
Pyrrolo[2,3-b]pyridine derivative 3	DMCYOL7	Chronic pain	MG30	Patented	[12]
Pyrrolo[2,3-d]pyrimidine derivative 3	DMTX1G4	Chronic pain	MG30	Patented	[12]
Pyrrolo[2,3-d]pyrimidine derivative 4	DME0WSR	Chronic pain	MG30	Patented	[12]
Pyrrolo[3,2-c]pyridine derivative 1	DMKF8HI	Chronic pain	MG30	Patented	[12]
Six-membered heterocyclic benzamide derivative 1	DMYFK85	Chronic pain	MG30	Patented	[12]
Six-membered heterocyclic benzamide derivative 2	DMX6AKV	Chronic pain	MG30	Patented	[12]
Six-membered heterocyclic benzamide derivative 3	DMEGVD4	Chronic pain	MG30	Patented	[12]
Six-membered heterocyclic benzamide derivative 4	DMB0D1H	Chronic pain	MG30	Patented	[12]
Six-membered heterocyclic benzamide derivative 5	DM0GTUH	Chronic pain	MG30	Patented	[12]
Six-membered heterocyclic benzamide derivative 6	DMZU96C	Chronic pain	MG30	Patented	[12]
Six-membered heterocyclic benzamide derivative 7	DM15AFI	Chronic pain	MG30	Patented	[12]
Thiadiazolyl carboxamide derivative 1	DMX93AI	Alzheimer disease	8A20	Patented	[8]
Thiazole derivative 4	DM5UQK6	N. A.	N. A.	Patented	[8]
Tri-substituted urea derivative 1	DMHGRTX	Chronic pain	MG30	Patented	[12]
Tri-substituted urea derivative 2	DMUVPR8	Chronic pain	MG30	Patented	[12]
Triazolo[4,3-b]pyridazine derivative 2	DMMJ1FN	Chronic pain	MG30	Patented	[12]
Ureido-phenyl-substituted triazine derivative 1	DMN51XF	N. A.	N. A.	Patented	[8]
Ureido-phenyl-substituted triazine derivative 2	DMR0JDW	N. A.	N. A.	Patented	[8]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD6918	DM2QHVW	Advanced solid tumour	2A00-2F9Z	Discontinued in Phase 1	[13]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FX-007	DMXE6ML	Pain	MG30-MG3Z	Preclinical	[14]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CEP-5104	DMV43GY	Discovery agent	N.A.	Investigative	[15]
CEP-6331	DMNXBTD	Discovery agent	N.A.	Investigative	[15]
GW-5074	DMIHOYF	Discovery agent	N.A.	Investigative	[16]
K-252a analogue	DMCZPH4	Discovery agent	N.A.	Investigative	[17]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [2] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye. Clin Ophthalmol. 2013; 7: 1275-1285.
• [5] Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis. Acta Derm Venereol. 2015 May;95(5):542-8.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751.
• [9] National Cancer Institute Drug Dictionary (drug id 766123).
• [10] National Cancer Institute Drug Dictionary (drug id 747694).
• [11] ClinicalTrials.gov (NCT03556228) Oral TrkA Inhibitor VMD-928 for Treatment of Advanced Adult Solid Tumors or Lymphoma. U.S. National Institutes of Health.
• [12] Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849.
• [13] Clinical pipeline report, company report or official report of AstraZeneca (2009).
• [14] Preclinical trail of FX007 for treating osteoarthritis. Flexion Therapeutics Inc.
• [15] Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9.
• [16] Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.
• [17] Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on tr... J Med Chem. 2005 Jun 2;48(11):3776-83.