Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTTQGH8)

• DTT Name: Histone deacetylase 4 (HDAC4) DTT Info
• UniProt ID: HDAC4_HUMAN
• Gene Name: HDAC4

Molecule-Related Drug & Molecule List

23 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29671355-Compound-12	DMBQOW4	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-45a	DM5LYKR	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-47a	DM5I1QV	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-47b	DMBUJ39	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-47c	DMAH982	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-47d	DMPA9OY	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-50	DMLDFVN	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-52	DMEUZM3	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-61	DMXH1G3	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-68b	DMLGBR6	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-70	DM394WH	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-71a	DMUAC1T	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-71b	DM8VG4Q	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-72a	DMICDV6	N. A.	N. A.	Patented	[1]
PMID29671355-Compound-72b	DM08OV7	N. A.	N. A.	Patented	[1]

81 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one	DM5LSY9	Discovery agent	N.A.	Investigative	[2]
2,2-bis(3-fluorophenyl)-N-hydroxyacetamide	DMTODR2	Discovery agent	N.A.	Investigative	[3]
2,2-bis(4-chlorophenyl)-N-hydroxyacetamide	DM2RKD6	Discovery agent	N.A.	Investigative	[3]
2,2-bis(4-fluorophenyl)-N-hydroxyacetamide	DM5PWQM	Discovery agent	N.A.	Investigative	[3]
2-(methylsulfonylthio)ethyl 2-propylpentanoate	DMM52D3	Discovery agent	N.A.	Investigative	[4]
4-Benzoylamino-N-hydroxy-benzamide	DMYBPFS	Discovery agent	N.A.	Investigative	[5]
4-Butyrylamino-N-hydroxy-benzamide	DMRY6B4	Discovery agent	N.A.	Investigative	[6]
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide	DM5AVG3	Discovery agent	N.A.	Investigative	[7]
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide	DM0M8G5	Discovery agent	N.A.	Investigative	[8]
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide	DMULOHZ	Discovery agent	N.A.	Investigative	[9]
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide	DM6CRVS	Discovery agent	N.A.	Investigative	[10]
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione	DM7KQXL	Discovery agent	N.A.	Investigative	[4]
5-Mercapto-pentanoic acid phenylamide	DMET3OJ	Discovery agent	N.A.	Investigative	[8]
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide	DM9LKXD	Discovery agent	N.A.	Investigative	[8]
6-benzenesulfinylhexanoic acid hydroxamide	DM2I95Z	Discovery agent	N.A.	Investigative	[11]
6-benzenesulfonylhexanoic acid hydroxamide	DMY9IK8	Discovery agent	N.A.	Investigative	[11]
6-Mercapto-hexanoic acid phenylamide	DMD2FW9	Discovery agent	N.A.	Investigative	[8]
6-Phenoxy-hexane-1-thiol	DMVYIN2	Discovery agent	N.A.	Investigative	[8]
6-phenylsulfanylhexanoic acid hydroxamide	DM3OLM6	Discovery agent	N.A.	Investigative	[11]
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one	DMLCGSY	Discovery agent	N.A.	Investigative	[2]
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one	DM28GZ7	Discovery agent	N.A.	Investigative	[7]
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one	DMY027P	Discovery agent	N.A.	Investigative	[2]
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one	DM4VQN8	Discovery agent	N.A.	Investigative	[2]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide	DMPYTHV	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid biphenyl-3-ylamide	DMEQKPO	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid biphenyl-4-ylamide	DMJMOUK	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid phenylamide	DM4912P	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid pyridin-3-ylamide	DMQ9PLA	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid quinolin-3-ylamide	DMTAGJ1	Discovery agent	N.A.	Investigative	[8]
7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide	DM03XYF	Discovery agent	N.A.	Investigative	[12]
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one	DM23XGW	Discovery agent	N.A.	Investigative	[2]
8-Mercapto-octanoic acid phenylamide	DMD3FWU	Discovery agent	N.A.	Investigative	[8]
8-Oxo-8-phenyl-octanoic acid	DMXDQ25	Discovery agent	N.A.	Investigative	[9]
8-Oxo-8-phenyl-octanoic acid hydroxyamide	DMWM1UL	Discovery agent	N.A.	Investigative	[7]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide	DMVBCID	Discovery agent	N.A.	Investigative	[7]
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one	DMIY3D6	Discovery agent	N.A.	Investigative	[7]
AZUMAMIDE B	DMXOGE8	Discovery agent	N.A.	Investigative	[13]
AZUMAMIDE C	DMEBA61	Discovery agent	N.A.	Investigative	[13]
AZUMAMIDE E	DMAX06G	Discovery agent	N.A.	Investigative	[13]
Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-)	DMZF35W	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-)	DMIVREK	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-)	DMLBECR	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-)	DMA76KW	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-)	DMLNJ0O	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-)	DMTVMWA	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-)	DMUSEDF	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-)	DMSEQ0W	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-)	DMBKP48	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-)	DMVY89X	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-)	DMTDIM9	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-)	DMV23XD	Discovery agent	N.A.	Investigative	[14]
Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-)	DM0VIH4	Discovery agent	N.A.	Investigative	[14]
Cyclostellettamine derivative	DMFTDPQ	Discovery agent	N.A.	Investigative	[15]
LARGAZOLE	DMSYLIJ	Discovery agent	N.A.	Investigative	[16]
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide	DM0GOPV	Discovery agent	N.A.	Investigative	[17]
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide	DMJLFOQ	Discovery agent	N.A.	Investigative	[17]
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide	DMSUW7M	Discovery agent	N.A.	Investigative	[7]
N-(6-Hydroxycarbamoyl-hexyl)-benzamide	DMIZVMT	Discovery agent	N.A.	Investigative	[9]
N-(6-Mercapto-hexyl)-benzamide	DM01Y37	Discovery agent	N.A.	Investigative	[8]
N-hydroxy-2,2-diphenylacetamide	DMX3KRQ	Discovery agent	N.A.	Investigative	[3]
N-hydroxy-2,2-diphenylpropanamide	DM7I2TD	Discovery agent	N.A.	Investigative	[3]
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide	DMCN91A	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide	DMVK2Y3	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide	DMHEQ41	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide	DMUOCQB	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide	DMVEOBY	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide	DMISRMT	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide	DMGTNQY	Discovery agent	N.A.	Investigative	[6]
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide	DMDUOH4	Discovery agent	N.A.	Investigative	[6]
N-Hydroxy-4-phenylacetylamino-benzamide	DMCRU17	Discovery agent	N.A.	Investigative	[5]
N-hydroxy-9,10-dihydroanthracene-9-carboxamide	DMID3BF	Discovery agent	N.A.	Investigative	[3]
N-hydroxy-9H-xanthene-9-carboxamide	DM0DRHP	Discovery agent	N.A.	Investigative	[3]
Octanedioic acid bis-hydroxyamide	DMJNQ9K	Discovery agent	N.A.	Investigative	[18]
Octanedioic acid hydroxyamide pyridin-2-ylamide	DMHNWS1	Discovery agent	N.A.	Investigative	[9]
Octanedioic acid hydroxyamide pyridin-4-ylamide	DM945RK	Discovery agent	N.A.	Investigative	[9]
PSAMMAPLIN A	DM6T0IQ	Discovery agent	N.A.	Investigative	[7]
santacruzamate A	DMFAM7P	Discovery agent	N.A.	Investigative	[19]
ST-2987	DMWXTM8	Solid tumour/cancer	2A00-2F9Z	Investigative	[20]
ST-3050	DM19K2D	Discovery agent	N.A.	Investigative	[20]
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester	DMBOKSF	Discovery agent	N.A.	Investigative	[8]
TMP269	DMSMQE7	Discovery agent	N.A.	Investigative	[21]

References

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• [3] Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8.
• [4] New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7.
• [5] Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5.
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• [7] Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116.
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• [10] Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.
• [11] Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5.
• [12] Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38.
• [13] Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4.
• [14] Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9.
• [15] Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.
• [16] Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues. J Med Chem. 2010 Jun 24;53(12):4654-67.
• [17] Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72.
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• [19] Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33.
• [20] N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9.
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