Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTTV8EJ)

• DTT Name: Serine/threonine-protein kinase Sgk1 (SGK1) DTT Info
• UniProt ID: SGK1_HUMAN
• Gene Name: SGK1

Molecule-Related Drug & Molecule List

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[1]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[2]
CGP-57380	DMFPOUC	Discovery agent	N.A.	Investigative	[3]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[2]
GSK-650394	DMNRP2L	Prostate cancer	2C82.0	Investigative	[4]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[2]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[2]

References

• [1] Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
• [2] Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
• [3] The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8040).