General Information of DTT (ID: TTUF2HO)

DTT Name NAD-dependent deacetylase sirtuin-1 (SIRT1) DTT Info
Gene Name SIRT1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
6 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1]
GSK2245840 DMG7YQL Chronic obstructive pulmonary disease CA22 Phase 2 [2]
MB-12066 DMRSN2C Obesity 5B81 Phase 2 [3]
SEN-196 DMLDBQ5 Huntington disease 8A01.10 Phase 2 [4]
SRT2379 DM7DAKX Type-2 diabetes 5A11 Phase 1 [5]
SRT3025 DMRAXFH Type-2 diabetes 5A11 Phase 1 [6]
------------------------------------------------------------------------------------
⏷ Show the Full List of 6 Clinical Trial Drug(s)
4 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CAMBINOL DMW46GY Discovery agent N.A. Patented [7]
PMID25435179-Compound-WO2012106509CAY10602 DM2F1T0 N. A. N. A. Patented [1]
PMID25435179-Compound-WO2012106509Salermide DMLAH39 N. A. N. A. Patented [1]
PMID25435179-Compound-WO2012106509Tenovin-6 DMBSOED N. A. N. A. Patented [1]
------------------------------------------------------------------------------------
1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK184072 DMMIR1K Colon cancer 2B90.Z Discontinued in Phase 2 [8]
------------------------------------------------------------------------------------
11 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(R)-sirtinol DMV1IS8 Discovery agent N.A. Investigative [9]
(S)-sirtinol DMS8WG3 Discovery agent N.A. Investigative [9]
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide DMXAS25 Discovery agent N.A. Investigative [10]
2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione DMET6FO Discovery agent N.A. Investigative [11]
Meta-sirtinol DMSK0QX Discovery agent N.A. Investigative [9]
Para-sirtinol DM83C9N Discovery agent N.A. Investigative [9]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [12]
Ro31-8220 DMDJLF0 Discovery agent N.A. Investigative [12]
splitomicin DMCLHZ5 Discovery agent N.A. Investigative [11]
SRT1720 DMUKVHQ Discovery agent N.A. Investigative [13]
YK-3237 DMU0NHX Solid tumour/cancer 2A00-2F9Z Investigative [14]
------------------------------------------------------------------------------------
⏷ Show the Full List of 11 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15.
2 Sirtuin 1 activator SRT2104 protects Huntington's disease mice. Ann Clin Transl Neurol. 2014 Dec;1(12):1047-52.
3 Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.PLoS One.2013 Jun 10;8(6):e64953.
4 Sirtuin 1 (SIRT1): the misunderstood HDAC. J Biomol Screen. 2011 Dec;16(10):1153-69.
5 SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model. Critical Care 2013, 17(Suppl 4):P8.
6 The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS One. 2015 Jul 30;10(7):e0134391.
7 Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity. J Med Chem. 2009 May 14;52(9):2673-82.
8 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
9 Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.
10 Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.
11 Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specif... J Med Chem. 2010 Feb 11;53(3):1407-11.
12 Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem. 2006 Dec 14;49(25):7307-16.
13 Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6.
14 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2707).