Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTUJFD0)

• DTT Name: Telomerase reverse transcriptase (TERT) DTT Info
• Gene Name: TERT

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[1]

14 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GV1001	DMHULRK	Pancreatic cancer	2C10	Phase 3	[2]
Imetelstat	DMONWJ4	Myelodysplastic syndrome	2A37	Phase 2/3	[3]
VM1500A	DM9YSSY	Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[4]
CB-10-01	DM2IFYZ	Melanoma	2C30	Phase 2	[5]
Dendritic cell vaccine	DML4PMG	Ovarian cancer	2C73	Phase 2	[6]
GRNVAC1	DMAHOEP	Acute myeloid leukaemia	2A60	Phase 2	[7]
Vx-001	DMDKWA3	Breast cancer	2C60-2C65	Phase 2	[8]
Epithalon	DMWSGZU	Ocular inflammation	9C61.24	Phase 1/2	[9]
OBP-301	DM9MF08	Breast cancer	2C60-2C65	Phase 1/2	[10]
AAV-hTERT	DMV1J21	Aging	MG2A	Phase 1	[11]
DC/I540/KLH vaccine	DM6K47B	Brain cancer	2A00	Phase 1	[12]
GRN163	DMGF71W	Multiple myeloma	2A83	Phase 1	[13]
KML-001	DM1D2O0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[14]
TeloB-Vax	DMZG9U0	Prostate cancer	2C82.0	Phase 1	[15]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,3,7-trichloro-5-nitroquinoxaline (TNQX)	DMCKO6T	Discovery agent	N.A.	Investigative	[16]
PPA	DM86ZL2	Discovery agent	N.A.	Investigative	[17]
Telomestatin	DM6EIVM	Multiple myeloma	2A83	Investigative	[13]
TMPyP4	DMWO85H	Multiple myeloma	2A83	Investigative	[13]

References

• [1] Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol Int. 2002 Mar;51(1):99-103.
• [2] Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer. 2006 Dec 4;95(11):1474-82.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida(?)) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1056-1060.
• [5] Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26;5:12.
• [6] In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. J Immunotoxicol. 2009 Dec;6(4):243-8.
• [7] Targeting telomerase-expressing cancer cells. J Cell Mol Med. 2011 Jul;15(7):1433-42.
• [8] Clinical pipeline report, company report or official report of Vaxon-biotech.
• [9] Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
• [10] Telomerase-specific replication-selective virotherapy for human cancer. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):285-92.
• [11] ClinicalTrials.gov (NCT04110964) Evaluation of Safety and Tolerability of Libella Gene Therapy (LGT) for Critical Limb Ischemia: AAV- hTERT. U.S.National Institutes of Health.
• [12] Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clin Cancer Res. 2004 Feb 1;10(3):828-39.
• [13] Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
• [14] National Cancer Institute Drug Dictionary (drug id 672554).
• [15] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [16] Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells. Biochem J. 2003 Jul 15;373(Pt 2):523-9.
• [17] Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology. 2004 May;126(5):1337-46.