General Information of DTT (ID: TTUMGNO)

DTT Name Ornithine decarboxylase (ODC1) DTT Info
Gene Name ODC1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Investigative Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eflornithine DMJOQM3 African trypanosomiasis 1F51 Approved [1]
------------------------------------------------------------------------------------
1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Putrescine DMWE6V1 Burn and burn infection ND90-NE2Z Discontinued in Phase 2 [2]
------------------------------------------------------------------------------------
16 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(2R,5R)-delta-methyl-alpha-acetylenic putrescine DMSFXEO Discovery agent N.A. Investigative [1]
1-Amino-3-(aminoxy)-2-propanol Dihydrochloride DMOAQC4 Discovery agent N.A. Investigative [3]
3-(Aminooxy)propan-1-amine hydrochloride DMPFH15 Discovery agent N.A. Investigative [3]
3-methoxy-4-hydroxylonchocarpin DMAL1CP Discovery agent N.A. Investigative [4]
4-hydroxylonchocarpin DM36PHM Discovery agent N.A. Investigative [4]
Alpha-monofluoromethyl-3,4-dehydroornithine DML7SU3 Discovery agent N.A. Investigative [1]
Alpha-monofluoromethyl-3,4-dehydroornithine ethyl ester DMJTGZV Discovery agent N.A. Investigative [1]
Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester DMGI9SM Discovery agent N.A. Investigative [1]
AMXT-1501 DMPSRZ0 Head and neck cancer 2D42 Investigative [5]
APA DMVG3K1 Discovery agent N.A. Investigative [6]
G418 DMKTJBU Discovery agent N.A. Investigative [2]
LONCHOCARPUSONE DMWFAPJ Discovery agent N.A. Investigative [4]
N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO Discovery agent N.A. Investigative [2]
N-Pyridoxyl-Glycine-5-Monophosphate DMMV1YN Discovery agent N.A. Investigative [2]
Pyridoxine-5'-Phosphate DMFUNL1 Discovery agent N.A. Investigative [2]
ZAPOTIN DMM4ZKU Discovery agent N.A. Investigative [7]
------------------------------------------------------------------------------------
⏷ Show the Full List of 16 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6.
4 New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).
6 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.
7 Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.