Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTV8KWS)

• DTT Name: Vesicular acetylcholine transporter (SLC18A3) DTT Info
• Gene Name: SLC18A3

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
T-588	DM3M5TU	Amyotrophic lateral sclerosis	8B60.0	Discontinued in Phase 2	[1]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
aminobenzovesamicol	DMCILV7	Discovery agent	N.A.	Investigative	[2]
vesamicol	DMHKUBG	Discovery agent	N.A.	Investigative	[2]
[123I]iodobenzovesamicol	DMOZGLM	Discovery agent	N.A.	Investigative	[3]
[3H]vesamicol	DM3MK8S	Discovery agent	N.A.	Investigative	[4]

References

• [1] Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices: existence of functional Na(+)-independent transporter activity. Neurochem Int. 2001 Apr;38(4):323-31.
• [2] Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor. Biochem Pharmacol. 1995 Mar 15;49(6):791-7.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1013).
• [4] Active transport of acetylcholine by the human vesicular acetylcholine transporter. J Biol Chem. 1996 Nov 1;271(44):27229-32.