Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTVPQTF)

• DTT Name: Glutamate receptor AMPA 1 (GRIA1) DTT Info
• Gene Name: GRIA1

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[2]

6 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[3]
Farampator	DM76GRQ	Major depressive disorder	6A70.3	Discontinued in Phase 1	[4]
GYKI-52466	DM3YG5P	Alzheimer disease	8A20	Terminated	[5]
GYKI-53655	DMC0JN8	N. A.	N. A.	Terminated	[6]
SORETOLIDE	DMTDLHG	Convulsion	8A68.Z	Terminated	[7]
Zonampanel	DM70HZD	N. A.	N. A.	Terminated	[3]

15 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-5-fluorowillardiine	DMCIZ7P	Discovery agent	N.A.	Investigative	[8]
(S)-AMPA	DMNJSTM	Discovery agent	N.A.	Investigative	[9]
(S)-WILLARDIINE	DMXQ47M	Discovery agent	N.A.	Investigative	[10]
7-chloro-3-hydroxyquinazoline-2,4-dione	DM3OMLU	Discovery agent	N.A.	Investigative	[2]
Argiotoxin-636	DMQ1DWU	Discovery agent	N.A.	Investigative	[11]
ATPO	DMXLS78	Discovery agent	N.A.	Investigative	[8]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[12]
joro toxin	DMYBJ4K	Discovery agent	N.A.	Investigative	[8]
N-(4-hydroxyphenylpropanyl)-spermine	DM4QR2C	Discovery agent	N.A.	Investigative	[11]
Philanthotoxin-343	DMP3MOC	Discovery agent	N.A.	Investigative	[11]
Piriqualone	DM7XTHD	Discovery agent	N.A.	Investigative	[13]
RPR-118723	DMLDWCB	Discovery agent	N.A.	Investigative	[14]
[3H]AMPA	DMLF7SG	N. A.	N. A.	Investigative	[8]
[3H]CNQX	DMIFKUX	Discovery agent	N.A.	Investigative	[8]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[15]

References

• [1] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [2] Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26.
• [3] Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11.
• [4] The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
• [5] New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70.
• [6] Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. J Med Chem. 1996 Jan 19;39(2):343-6.
• [7] Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol Scand Suppl. 2013;(197):19-24.
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444).
• [9] Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48(24):7867-81.
• [10] Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem. 1997 Oct 24;40(22):3645-50.
• [11] Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1381-7.
• [12] Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.
• [13] Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antag... Bioorg Med Chem Lett. 2001 Jan 22;11(2):177-81.
• [14] Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81.
• [15] 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of pot... J Med Chem. 2008 Oct 23;51(20):6614-8.