Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTWRN6M)

• DTT Name: CRP messenger RNA (CRP mRNA) DTT Info
• UniProt ID: CRP_HUMAN
• Gene Name: CRP

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS-CRPRx	DML84CN	Coronary artery disease	BA80	Phase 2	[1]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[2], [3]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 133712	DMDZ3FU	Discovery agent	N.A.	Investigative	[4]
ISIS 133726	DMJ56XU	Discovery agent	N.A.	Investigative	[4]
ISIS 140180	DMP9WOZ	Discovery agent	N.A.	Investigative	[4]
ISIS 329956	DMA96KW	Discovery agent	N.A.	Investigative	[4]
ISIS 330012	DMWIVS9	Discovery agent	N.A.	Investigative	[4]
ISIS 330031	DM35WFL	Discovery agent	N.A.	Investigative	[4]
Phosphocholine	DMIZLVW	Discovery agent	N.A.	Investigative	[5]

References

• [1] Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies. J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):49-60.
• [2] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
• [3] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
• [4] US patent application no. 7,425,545, Modulation of C-reactive protein expression.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.