Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTYDSVG)

• DTT Name: Syndecan-1 (SDC1) DTT Info
• Gene Name: SDC1

Molecule-Related Drug & Molecule List

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BT-062	DMYO185	Multiple myeloma	2A83	Phase 2	[1]
CART-138 cells	DMB4HEW	Multiple myeloma	2A83	Phase 1/2	[2]
CD138 CAR T cells	DMCSGNU	Multiple myeloma	2A83	Phase 1/2	[3]
CAR138 T Cells	DMA9M81	Immune System disease	4A01-4B41	Phase 1	[4]
CAR-T cells targeting CD138	DMHBQYU	Multiple myeloma	2A83	Clinical trial	[5]

References

• [1] The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res. 2009 Jun 15;15(12):4028-37.
• [2] ClinicalTrials.gov (NCT01886976) Treatment of Chemotherapy Refractory Multiple Myeloma by CART-138
• [3] ClinicalTrials.gov (NCT03271632) Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma
• [4] ClinicalTrials.gov (NCT03672318) Study of ATLCAR.CD138 Cells for Relapsed/Refractory Multiple Myeloma
• [5] ClinicalTrials.gov (NCT03473496) CAR-T Cells Therapy in Relapsed/Refractory Multiple Myeloma