Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTYLQ8V)

• DTT Name: Prostaglandin E synthase (PTGES) DTT Info
• Gene Name: PTGES

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AAD-2004	DMG4RK0	Alzheimer disease	8A20	Phase 1	[1]

31 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-substituted pirinixic acid and pirinixic acid ester derivative 1	DMWX0QK	N. A.	N. A.	Patented	[2]
Benzamide derivative 14	DMP2LDC	N. A.	N. A.	Patented	[2]
Benzamide derivative 15	DMAEBJ4	N. A.	N. A.	Patented	[2]
Benzamide derivative 16	DMOAXKF	N. A.	N. A.	Patented	[2]
Benzamide derivative 18	DMD7640	N. A.	N. A.	Patented	[2]
Benzimidazole derivative 11	DMGRD8B	N. A.	N. A.	Patented	[2]
Benzimidazole derivative 12	DMOHERV	N. A.	N. A.	Patented	[2]
Benzimidazole derivative 13	DMV4DQI	N. A.	N. A.	Patented	[2]
Benzimidazole derivative 14	DMCY5M7	N. A.	N. A.	Patented	[2]
Benzimidazole derivative 15	DMJ3AZ4	N. A.	N. A.	Patented	[2]
Benzimidazole derivative 16	DMHEQDT	N. A.	N. A.	Patented	[2]
Benzimidazole derivative 17	DM1DXME	N. A.	N. A.	Patented	[2]
Betais-sulfonylamino derivative 1	DMMCDR7	N. A.	N. A.	Patented	[2]
Boswellia acid derivative 1	DMCLB5D	N. A.	N. A.	Patented	[2]
Carboxylic acid derivative 1	DM86E2P	Angiogenesis disorder	BE2Z	Patented	[2]
Imidazole benzamide derivative 1	DM0SOKJ	Knee pain	ME82	Patented	[2]
Imidazopyridine derivative 5	DMUKBGD	N. A.	N. A.	Patented	[2]
Imidazopyridine derivative 6	DMA0V4F	N. A.	N. A.	Patented	[2]
Imidazopyridine derivative 7	DMI3XPJ	N. A.	N. A.	Patented	[2]
Methyl-piperidine compound 1	DM5PS6K	Angiogenesis disorder	BE2Z	Patented	[2]
Phthalazinone derivative 1	DMNA941	N. A.	N. A.	Patented	[2]
Piperidine carboxamide derivative 1	DMY8QIG	N. A.	N. A.	Patented	[2]
PMID28627961-Compound-22	DM36P7T	N. A.	N. A.	Patented	[2]
PMID28627961-Compound-30	DMRLU8I	N. A.	N. A.	Patented	[2]
PMID28627961-Compound-31	DMLGYXW	N. A.	N. A.	Patented	[2]
PMID28627961-Compound-32	DM5IZKD	N. A.	N. A.	Patented	[2]
PMID28627961-Compound-33	DMWV4YE	N. A.	N. A.	Patented	[2]
PMID28627961-Compound-41	DMODL3P	N. A.	N. A.	Patented	[2]
PMID28627961-Compound-44	DM7ATLP	N. A.	N. A.	Patented	[2]
Polycyclic compound 1	DMSWI67	N. A.	N. A.	Patented	[2]
Pyrimidine derivative 2	DMS8OR3	N. A.	N. A.	Patented	[2]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-655240	DMGX3MK	N. A.	N. A.	Terminated	[3]

References

• [1] Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.
• [2] Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059.
• [3] Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3352-5.