Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZAT79)

• DTT Name: T-cell surface glycoprotein CD3 epsilon (CD3E) DTT Info
• Gene Name: CD3E

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Muromonab	DM8ANCF	Organ transplant rejection	NE84	Approved	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ertumaxomab	DM5Z3VP	Breast cancer	2C60-2C65	Phase 2	[2]
Resimmune	DMT5QSD	Cutaneous T-cell lymphoma	2B01	Phase 2	[3]
Autologous T-cell therapy	DMOAET3	Prostate cancer	2C82.0	Phase 1	[4]
MT-110	DMPCUN5	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]

References

• [1] Basiliximab: a review of its use as induction therapy in renal transplantation. Drugs. 2003;63(24):2803-35.
• [2] Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22.
• [3] Resimmune, an anti-CD3 recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma.Haematologica.2015 Jun;100(6):794-800.
• [4] Antitumor activities of PSMA CD3 diabodies by redirected T-cell lysis of prostate cancer cells. Immunotherapy. 2013 Jan;5(1):27-38.
• [5] EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74.