Details of Disease

General Information of Disease (ID: DIS0NDAM)

Disease Name Striatonigral degeneration
Definition
A progressive neurodegenerative disorder caused by a disruption in the connection between the striatum and the substantia nigra. It is a type of multiple system atrophy (MSA). Signs and symptoms include rigidity, instability, impaired speech, and slow movements.
Disease Hierarchy
DISASEYE: Multiple system atrophy
DIS0NDAM: Striatonigral degeneration
Disease Identifiers
MONDO ID
MONDO_0003122
MESH ID
D020955
UMLS CUI
C0270733
MedGen ID
124366
SNOMED CT ID
29618004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
COQ2 OTDAKEY4 Limited SusceptibilityMutation [1]
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References

1 Mutations in COQ2 in familial and sporadic multiple-system atrophy.N Engl J Med. 2013 Jul 18;369(3):233-44. doi: 10.1056/NEJMoa1212115. Epub 2013 Jun 12.