Details of Disease | DrugMAP

General Information of Disease (ID: DIS13CUJ)

Disease Name	Hyperthyroxinemia
Definition	Abnormally elevated thyroxine level in the blood.
Disease Hierarchy	DIS5T3X5: Thyroid disease DIS13CUJ: Hyperthyroxinemia
Disease Identifiers	MONDO ID MONDO_0005333 MESH ID D006981 UMLS CUI C0020551 MedGen ID 6973

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DIO1	TTU3X26	Limited	Biomarker	[1]
TTR	TTPOYU7	Strong	Genetic Variation	[2]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH5	DEIOH6A	Strong	Genetic Variation	[3]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ALDH1L1	OT15HOJX	Strong	Genetic Variation	[3]
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References

1	Euthyroid hyperthyroxinemia due to a generalized 5'-deiodinase defect.J Clin Endocrinol Metab. 1988 Apr;66(4):684-8. doi: 10.1210/jcem-66-4-684.
2	Transthyretin mutations in hyperthyroxinemia and amyloid diseases.Hum Mutat. 2001 Jun;17(6):493-503. doi: 10.1002/humu.1132.
3	Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia.Front Endocrinol (Lausanne). 2017 Nov 1;8:297. doi: 10.3389/fendo.2017.00297. eCollection 2017.