Details of Disease | DrugMAP

General Information of Disease (ID: DIS141UP)

Disease Name	Nervous system neoplasm
Synonyms	neoplasm of nervous system; tumor of the nervous system; tumor of nervous system; neoplasm of the nervous system; tumour of nervous system; nervous system tumor; nervous system neoplasms; tumour of the nervous system; nervous system tumour; nervous system neoplasm (disease)
Definition	A neoplasm (disease) that involves the nervous system.
Disease Hierarchy	DISTBY9Z: Tumour DISCFBRD: Neurological disorder DIS141UP: Nervous system neoplasm
Disease Identifiers	MONDO ID MONDO_0021248 MESH ID D009423 UMLS CUI C0027766 MedGen ID 45046 HPO ID HP:0004375 SNOMED CT ID 126950007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GLIPR1	TTEQF1O	Strong	Altered Expression	[1]
NF2	TTZIK7P	Strong	Biomarker	[2]
PTN	TTA9EJK	Strong	Biomarker	[3]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ENC1	OTJEUB6U	Strong	Altered Expression	[4]
LNX1	OTZWFMAZ	Strong	Biomarker	[5]
LZTR1	OTIDM6XO	Strong	Biomarker	[6]
NAV3	OT97M1TR	Strong	Genetic Variation	[7]
NR2E1	OTW47GKM	Strong	Altered Expression	[8]
RAB3A	OT2GIUO5	Strong	Altered Expression	[9]
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⏷ Show the Full List of 6 DOT(s)

References

1	The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors.Gene. 1995 Jun 14;159(1):131-5. doi: 10.1016/0378-1119(95)00061-a.
2	MicroRNA?2a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells.Oncol Rep. 2019 Apr;41(4):2103-2116. doi: 10.3892/or.2019.7020. Epub 2019 Feb 19.
3	Roles of pleiotrophin in tumor growth and angiogenesis.Eur Cytokine Netw. 2009 Dec;20(4):180-90. doi: 10.1684/ecn.2009.0172.
4	Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors.Exp Cell Res. 1998 Aug 1;242(2):470-7. doi: 10.1006/excr.1998.4109.
5	Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors.Cancer Genet Cytogenet. 2008 Oct 15;186(2):103-9. doi: 10.1016/j.cancergencyto.2008.07.003.
6	Oligo-astrocytoma in LZTR1-related Noonan syndrome.Eur J Med Genet. 2020 Jan;63(1):103617. doi: 10.1016/j.ejmg.2019.01.007. Epub 2019 Jan 19.
7	Neuron navigator 3 alterations in nervous system tumors associate with tumor malignancy grade and prognosis.Genes Chromosomes Cancer. 2013 Feb;52(2):191-201. doi: 10.1002/gcc.22019. Epub 2012 Oct 25.
8	TLX-Its Emerging Role for Neurogenesis in Health and Disease.Mol Neurobiol. 2017 Jan;54(1):272-280. doi: 10.1007/s12035-015-9608-1. Epub 2016 Jan 6.
9	Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.Cancer. 1992 Nov 15;70(10):2552-6. doi: 10.1002/1097-0142(19921115)70:10<2552::aid-cncr2820701026>3.0.co;2-q.