Details of Disease

General Information of Disease (ID: DIS1KV65)

Disease Name Myelitis
Synonyms spinal cord inflammation; inflammation of spinal cord
Definition
An inflammatory process affecting the spinal cord. Causes include viral infections, autoimmune disorders, vascular disorders, and toxic agents. Symptoms include weakness, paresthesia, sensory loss, pain, and incontinence.
Disease Hierarchy
DISWD40R: Disease
DISXV8FG: Myelopathy
DISB3X5A: Nervous system inflammation
DIS1KV65: Myelitis
Disease Identifiers
MONDO ID
MONDO_0002565
MESH ID
D009187
UMLS CUI
C0026975
MedGen ID
10230
HPO ID
HP:0012486
SNOMED CT ID
41370002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
MOG TTQAFX5 Strong Biomarker [1]
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This Disease Is Related to 5 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
NEUROD4 OTGYOIOJ Limited Biomarker [2]
ASCC2 OT3B204T Strong Biomarker [3]
CD93 OT6HZT6H Strong Biomarker [4]
DPYSL5 OT6F9T6F Strong Biomarker [5]
OAS3 OT6E5FYS Strong Biomarker [3]
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References

1 MOG-IgG-associated demyelination: focus on atypical features, brain histopathology and concomitant autoimmunity.J Neurol. 2020 Feb;267(2):359-368. doi: 10.1007/s00415-019-09586-5. Epub 2019 Oct 22.
2 MiR-137 attenuates spinal cord injury by modulating NEUROD4 through reducing inflammation and oxidative stress.Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):1884-1890. doi: 10.26355/eurrev_201804_14709.
3 Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G.Mult Scler. 2017 Jul;23(8):1104-1111. doi: 10.1177/1352458516674366. Epub 2016 Oct 19.
4 CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis.Immunology. 2018 Nov;155(3):346-355. doi: 10.1111/imm.12974. Epub 2018 Jul 11.
5 Inflammatory flaccid myelitis in a patient with both anti-CRMP-5 IgG and CNS HIV escape.BMJ Case Rep. 2019 May 21;12(5):e228378. doi: 10.1136/bcr-2018-228378.