Details of Disease

General Information of Disease (ID: DIS1LDG6)

• Disease Name: Congenital alopecia
• Synonyms: ALPC; alopecia, congenital; congenital alopecia
• Disease Class: LC30: Hair/hair growth developmental defect
• Definition: A congenital condition characterized by the absence of hair on the scalp or entire body. The lack of hair is rarely absolute and is usually accompanied by incompletely grown, lanugo-like hair. It affects males twice as much as females and a familial tendency is common.
• Disease Hierarchy:
  DISCNJPF: Alopecia totalis
  DISYSLWA: Alopecia, isolated
  DIS1LDG6: Congenital alopecia
• ICD Code:
  ICD-11: ICD-11: LC30
  ICD-10: ICD-10: Q84.0
  Expand ICD-11: 'LC30
  Expand ICD-10: 'Q84.0
• Disease Identifiers:
  MONDO ID: MONDO_0010229
  MESH ID: C535981
  UMLS CUI: C0265992
  OMIM ID: 300042
  MedGen ID: 78581
  SNOMED CT ID: 2965006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Calcitriol	DM8ZVJ7	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FOXN1	OTE80D6I	Strong	Genetic Variation	[2]
HR	OTHEZWPW	Strong	Genetic Variation	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2779).
• [2] FOXN1 homozygous mutation associated with anencephaly and severe neural tube defect in human athymic Nude/SCID fetus.Clin Genet. 2008 Apr;73(4):380-4. doi: 10.1111/j.1399-0004.2008.00977.x.
• [3] A gene for universal congenital alopecia maps to chromosome 8p21-22.Am J Hum Genet. 1998 Feb;62(2):386-90. doi: 10.1086/301717.