Details of Disease | DrugMAP

General Information of Disease (ID: DIS1O1QK)

Disease Name	Postural orthostatic tachycardia syndrome
Synonyms	neurocirculatory asthenia; Soldiers heart; orthostatic intolerance; postural tachycardia syndrome due to NET deficiency; irritable heart; soldiers heart; familial orthostatic tachycardia due to norepinephrine transporter deficiency; orthostatic intolerance due to NET deficiency; POTS; orhtostatic intolerance
Definition	A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart.
Disease Hierarchy	DISMT2VZ: Cardiogenetic disease DIS5OMQ5: Inherited orthostatic hypotension DISLKUNL: Heart arrhythmia DIS1O1QK: Postural orthostatic tachycardia syndrome
Disease Identifiers	MONDO ID MONDO_0011479 MESH ID D054972 UMLS CUI C1299624 MedGen ID 226970 Orphanet ID 443236 SNOMED CT ID 371073003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC6A2	DT9JBVI	Supportive	Autosomal dominant	[1]
SLC44A1	DT3I2SU	Strong	Altered Expression	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SLC6A2	OTMHQJMP	Supportive	Autosomal dominant	[1]
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References

1	Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med. 2000 Feb 24;342(8):541-9. doi: 10.1056/NEJM200002243420803.
2	Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts.FASEB J. 2015 May;29(5):1663-75. doi: 10.1096/fj.14-258566. Epub 2014 Dec 2.