Details of Disease | DrugMAP

General Information of Disease (ID: DIS1WEB8)

Disease Name	Autosomal dominant Parkinson disease 4
Synonyms	autosomal dominant Parkinson's disease 4; Parkinson disease 4, autosomal dominant; PARK4; Parkinson disease 4, autosomal dominant Lewy body; autosomal dominant Parkinson disease type 4; autosomal dominant Parkinson disease 4; autosomal dominant Lewy body Parkinson disease 4
Definition	A late onset Parkinson disease that has material basis in heterozygous triplication of the alpha-synuclein gene (SNCA) on chromosome 4q22.
Disease Hierarchy	DIS9IOUI: Late-onset Parkinson disease DIS1WEB8: Autosomal dominant Parkinson disease 4
Disease Identifiers	MONDO ID MONDO_0011562 MESH ID C565324 UMLS CUI C1854182 OMIM ID 605543 MedGen ID 381361

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SNCA	TT08OSU	Definitive	Autosomal dominant	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SNCA	OTPWC1MR	Definitive	Autosomal dominant	[1]
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References

1	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.