Details of Disease | DrugMAP

General Information of Disease (ID: DIS2B7L2)

Disease Name	Frontotemporal dementia and/or amyotrophic lateral sclerosis
Disease Hierarchy	DISPN7D2: Inherited neurodegenerative disorder DIS2B7L2: Frontotemporal dementia and/or amyotrophic lateral sclerosis

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GRN	TT4LM0E	Definitive	Autosomal dominant	[1]
------------------------------------------------------------------------------------

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GRN	OTXXSJ53	Definitive	Autosomal dominant	[1]
------------------------------------------------------------------------------------

References

1	Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.