Details of Disease

General Information of Disease (ID: DIS2LR4O)

• Disease Name: Arterial thrombosis
• Synonyms: coronary vessel thrombotic disease; coronary artery thrombosis; thrombotic disease of coronary vessel
• Disease Class: DB61-DD30: Arterial thrombosis
• Definition: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.
• Disease Hierarchy:
  DIS5OIP1: Coronary heart disease
  DIS2TXP8: Thrombosis
  DIS2LR4O: Arterial thrombosis
• ICD Code:
  ICD-11: ICD-11: DB61-DD30
  ICD-10: ICD-10: I80-I82
  Expand ICD-9: 437.6,453,671.5,671.9
• Disease Identifiers:
  MONDO ID: MONDO_0006716
  MESH ID: D003328
  UMLS CUI: C0010072
  MedGen ID: 3625
  HPO ID: HP:0004420
  SNOMED CT ID: 398274000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Brilinta	DMBR01X	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Vonapanitase	DMC02MK	Phase 3	NA	[2]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SC-49992	DMY7KHW	Terminated	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PLA2G1B	TT9V5JH	moderate	Biomarker	[4]
PLA2G2A	TTO8QRU	moderate	Biomarker	[4]
GP6	TTTJUVZ	Strong	Genetic Variation	[5]
ITGB3	TTJA1ZO	Strong	Genetic Variation	[6]
PLAT	TTXAGYU	Strong	Therapeutic	[7]
TPSD1	TTNWD8O	Strong	Biomarker	[8]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PLA2G6	OT5FL0WU	moderate	Biomarker	[4]
GP5	OT3WGPR3	Strong	Genetic Variation	[9]
HPSE2	OTGEPP8V	Strong	Genetic Variation	[10]

References

• [1] ClinicalTrials.gov (NCT01732822) A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001873)
• [4] Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism.J Thorac Cardiovasc Surg. 2005 Sep;130(3):791-6. doi: 10.1016/j.jtcvs.2005.02.041.
• [5] Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men.Atherosclerosis. 2004 Sep;176(1):95-9. doi: 10.1016/j.atherosclerosis.2004.03.021.
• [6] Pro32Pro33 mutations in the integrin 3 PSI domain result in IIb3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.Mol Pharmacol. 2014 Jun;85(6):921-31. doi: 10.1124/mol.114.091736. Epub 2014 Apr 2.
• [7] Cocaine-induced coronary thrombosis and acute myocardial infarction.Int J Cardiol. 2004 Sep;96(3):481-2. doi: 10.1016/j.ijcard.2003.04.071.
• [8] Postmortem IgE determination in coronary artery disease.J Forensic Leg Med. 2019 Feb;62:1-6. doi: 10.1016/j.jflm.2018.12.006. Epub 2018 Dec 24.
• [9] The GPIIIa (beta3 integrin) PlA polymorphism in the early development of coronary atherosclerosis.Atherosclerosis. 2001 Feb 15;154(3):721-7. doi: 10.1016/s0021-9150(00)00683-3.
• [10] Platelet glycoprotein Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death.Circulation. 2001 Aug 21;104(8):876-80. doi: 10.1161/hc3301.094907.