Details of Disease

Disease Name

Hyperemesis gravidarum

pernicious vomiting of pregnancy; pregnancy pernicious vomiting; hyperemesis gravidarum (disease); hyperemesis gravidarum

Definition

Severe, intractable vomiting during pregnancy (usually the first trimester) accompanied by dehydration, weight loss, and electrolyte imbalances.

Disease Hierarchy

DIS5V7J6: Pregnancy disorder

DIS3YBRD: Hyperemesis gravidarum

Disease Identifiers

MONDO ID

MONDO_0006791

MESH ID

D006939

UMLS CUI

C0020450

MedGen ID

43776

HPO ID

HP:0012188

SNOMED CT ID

14094001

General Information of Disease (ID: DIS3YBRD)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Diphenhydramine	DMKQTBA	Approved	Small molecular drug	[1]
Promethazine	DM6I5GR	Approved	Small molecular drug	[2]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
[3H]thiamine	DMSHW2E	Investigative	Small molecular drug	[3]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IGFBP7	TTUQ01B	Limited	Altered Expression	[4]
GDF15	TT4MXVG	Strong	Altered Expression	[4]
GFRAL	TTE61UB	Strong	Genetic Variation	[5]
TSHR	TT6NYJA	Strong	Genetic Variation	[6]
------------------------------------------------------------------------------------

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BET1	OTGX2557	Strong	Biomarker	[7]
------------------------------------------------------------------------------------

References

1	Diphenhydramine FDA Label
2	Promethazine FDA Label
3	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
4	Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.Geburtshilfe Frauenheilkd. 2019 Apr;79(4):382-388. doi: 10.1055/a-0830-1346. Epub 2019 Feb 26.
5	Nausea and vomiting of pregnancy and hyperemesis gravidarum.Nat Rev Dis Primers. 2019 Sep 12;5(1):62. doi: 10.1038/s41572-019-0110-3.
6	Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor.J Clin Endocrinol Metab. 2016 Jan;101(1):10-1. doi: 10.1210/jc.2015-3670. Epub 2015 Nov 18.
7	BET 1: Haloperidol in cannabinoid hyperemesis syndrome.Emerg Med J. 2018 Nov;35(11):711-712. doi: 10.1136/emermed-2018-208170.1.