Details of Disease

General Information of Disease (ID: DIS45J3D)

• Disease Name: Post-traumatic epilepsy
• Synonyms: concussive convulsions; early post-traumatic seizures; concussive convulsion; post-traumatic seizures, late; epilepsy, post traumatic; late post-traumatic seizures; Epilepsies, post-traumatic; Epilepsies, traumatic; convulsion, concussive; post-traumatic seizure disorder; seizures, early post-traumatic; impact seizures; early post-traumatic seizure; post-traumatic seizure, early; seizure disorders, post-traumatic; PTE - post-traumatic epilepsy; post traumatic seizure disorder; seizure, early post-traumatic; traumatic Epilepsies; late post traumatic seizures; seizure disorder, post traumatic; seizure disorder, post-traumatic; post-traumatic seizure, late; disorder, post-traumatic seizure; post-traumatic seizures, early; epilepsy, traumatic; disorders, post-traumatic seizure; post-traumatic seizure disorders; early post traumatic seizures; late post-traumatic seizure; impact seizure; post-traumatic Epilepsies; seizures, late post-traumatic; seizure, late post-traumatic; convulsions, concussive; traumatic epilepsy; post-traumatic epilepsy
• Definition: Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)
• Disease Hierarchy:
  DISBB28L: Epilepsy
  DIS45J3D: Post-traumatic epilepsy
• Disease Identifiers:
  MONDO ID: MONDO_0043264
  MESH ID: D004834
  UMLS CUI: C0014557
  MedGen ID: 4991
  SNOMED CT ID: 75023009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Piracetam	DM5BXH9	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] A systematic review of levetiracetam versus phenytoin in the prevention of late post-traumatic seizures and survey of UK neurosurgical prescribing practice of antiepileptic medication in acute traumatic brain injury. Br J Neurosurg. 2018 Jun;32(3):237-244.