Details of Disease

General Information of Disease (ID: DIS45N3K)

Disease Name Growth hormone-producing pituitary gland adenoma
Synonyms
somatotropic adenoma; growth hormone-producing pituitary gland adenoma; somatotroph adenoma; growth hormone secreting adenoma of the pituitary gland; growth hormone producing adenoma of pituitary; growth hormone producing adenoma of the pituitary gland; growth hormone producing pituitary adenoma; GH cell adenoma; growth hormone secreting pituitary adenoma; growth hormone secreting adenoma of pituitary gland; growth hormone-producing adenoma; growth hormone secreting adenoma of pituitary; growth hormone producing pituitary gland adenoma; growth hormone secreting adenoma of the pituitary; Somatotrophinoma; growth hormone producing adenoma of the pituitary; growth hormone secreting pituitary gland adenoma; somatotrope adenoma; growth hormone producing adenoma of pituitary gland
Definition An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly.
Disease Hierarchy
DISJ5R1X: Pituitary adenoma
DISOQRTU: Growth hormone-producing pituitary gland neoplasm
DIS78ZEV: Adenoma
DIS45N3K: Growth hormone-producing pituitary gland adenoma
Disease Identifiers
MONDO ID
MONDO_0006238
UMLS CUI
C0278864
MedGen ID
82999
Orphanet ID
96256

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
SCG2 OTXWUQQL Limited Biomarker [1]
AIP OTDJ3OSV Strong Altered Expression [2]
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References

1 Characterization of the EM66 Biomarker in the Pituitary and Plasma of Healthy Subjects With Different Gonadotroph Status and Patients With Gonadotroph Tumor.Front Endocrinol (Lausanne). 2019 Feb 22;10:102. doi: 10.3389/fendo.2019.00102. eCollection 2019.
2 AIP and the somatostatin system in pituitary tumours.J Endocrinol. 2017 Dec;235(3):R101-R116. doi: 10.1530/JOE-17-0254. Epub 2017 Aug 23.