Details of Disease

General Information of Disease (ID: DIS4GOLF)

Disease Name	Appendicitis
Synonyms	acute appendicitis with peritoneal abscess; acute appendicitis; acute appendicitis with generalised peritonitis; acute appendicitis with generalized peritonitis; inflammation of vermiform appendix; vermiform appendix inflammation
Disease Class	DB10: Appendicitis
Definition	Acute inflammation of the vermiform appendix.
Disease Hierarchy	DISZMX6N: Cecal disorder DISWD40R: Disease DIS5PNPO: Disorder of appendix DISXQCG5: Gastroenteritis DIS4GOLF: Appendicitis
ICD Code	ICD-11 ICD-11: DB10 ICD-10 ICD-10: K37 Expand ICD-11 'DB10 Expand ICD-10 'K37
Disease Identifiers	MONDO ID MONDO_0005649 MESH ID D001064 UMLS CUI C0003615 MedGen ID 1630 HPO ID HP:6000143 SNOMED CT ID 74400008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
99mTc-fanolesomab	DMYFBMS	Approved	Antibody	[1]
Piperacillin	DMTBKF3	Approved	Small molecular drug	[2]
Ropivacaine	DMSPJG2	Approved	Small molecular drug	[3]
Tazobactam	DM3XNUI	Approved	Small molecular drug	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACR	TTAHE2N	moderate	Biomarker	[5]
NAGLU	TTDM6HZ	Strong	Biomarker	[6]
UCHL1	TTX9IFP	Definitive	Biomarker	[7]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ACSS2	DEE76VW	Strong	Genetic Variation	[8]
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This Disease Is Related to 11 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACCS	OTHIHI9D	Strong	Genetic Variation	[8]
CDS1	OT2F591M	Strong	Biomarker	[9]
DEFB103B	OT8RWY64	Strong	Altered Expression	[10]
MAGED2	OTMEWNSE	Strong	Altered Expression	[11]
MUSTN1	OTKO05K3	Strong	Biomarker	[12]
NBAS	OTW9IBRI	Strong	Biomarker	[6]
PLA2G15	OT6VJTPA	Strong	Genetic Variation	[8]
SCN7A	OTK05PXY	Strong	Biomarker	[6]
TFE3	OTM99ZWH	Strong	Biomarker	[13]
LRG1	OTLD0KWA	Definitive	Biomarker	[14]
PITX2	OTWMXAOY	Definitive	Biomarker	[15]
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⏷ Show the Full List of 11 DOT(s)

References

1	2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
2	Piperacillin FDA Label
3	Ropivacaine FDA Label
4	Tazobactam FDA Label
5	ACR Appropriateness Criteria() Suspected Appendicitis-Child.J Am Coll Radiol. 2019 May;16(5S):S252-S263. doi: 10.1016/j.jacr.2019.02.022.
6	Evaluation of the diagnostic performance of a decision tree model in suspected acute appendicitis with equivocal preoperative computed tomography findings compared with Alvarado, Eskelinen, and adult appendicitis scores: A STARD compliant article.Medicine (Baltimore). 2019 Oct;98(40):e17368. doi: 10.1097/MD.0000000000017368.
7	Concentration of UHCL1 in the Serum of Children with Acute Appendicitis, Before and After Surgery, and Its Correlation with CRP and Prealbumin.J Invest Surg. 2018 Apr;31(2):136-141. doi: 10.1080/08941939.2017.1282559. Epub 2017 Feb 27.
8	Imaging utilization affects negative appendectomy rates in appendicitis: An ACS-NSQIP study.Am J Surg. 2019 Jun;217(6):1094-1098. doi: 10.1016/j.amjsurg.2018.12.072. Epub 2019 Jan 3.
9	Implementation of an Electronic Clinical Decision Support Tool for Pediatric Appendicitis Within a Hospital Network.Pediatr Emerg Care. 2018 Jan;34(1):10-16. doi: 10.1097/PEC.0000000000001069.
10	Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.Innate Immun. 2015 Jan;21(1):30-41. doi: 10.1177/1753425913515033. Epub 2013 Dec 11.
11	Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed.Ann Surg. 2006 Jul;244(1):52-60. doi: 10.1097/01.sla.0000217617.06782.d5.
12	Complicated Appendicitis: Are Extended Antibiotics Necessary? A Post Hoc Analysis of the EAST Appendicitis "MUSTANG" Study.J Surg Res. 2020 Mar;247:508-513. doi: 10.1016/j.jss.2019.09.054. Epub 2019 Dec 4.
13	Transcription factor E3 protein-positive perivascular epithelioid cell tumor of the appendix presenting as acute appendicitis: a case report and review of the literature.Arch Pathol Lab Med. 2013 Mar;137(3):434-7. doi: 10.5858/arpa.2012-0103-CR.
14	A novel noninvasive appendicitis score with a urine biomarker.J Pediatr Surg. 2019 Jan;54(1):91-96. doi: 10.1016/j.jpedsurg.2018.10.025. Epub 2018 Oct 5.
15	Genetic association and differential expression of PITX2 with acute appendicitis.Hum Genet. 2019 Jan;138(1):37-47. doi: 10.1007/s00439-018-1956-2. Epub 2018 Nov 3.