Details of Disease

General Information of Disease (ID: DIS4X92K)

• Disease Name: Malignant tumor of parathyroid gland
• Synonyms: malignant tumor of the parathyroid gland; malignant parathyroid gland tumor; malignant parathyroid tumor; malignant tumour of the parathyroid gland; malignant parathyroid neoplasm; parathyroid gland cancer; cancer of parathyroid gland; malignant parathyroid gland neoplasm; malignant neoplasm of parathyroid; malignant parathyroid gland tumour; malignant tumor of parathyroid; malignant tumour of the parathyroid; malignant neoplasm of parathyroid gland; malignant neoplasm of the parathyroid gland; malignant neoplasm of the parathyroid; malignant tumor of the parathyroid; malignant tumour of parathyroid; parathyroid cancer; malignant parathyroid tumour
• Definition: A cancer that involves the parathyroid gland.
• Disease Hierarchy:
  :
  DISKTBM1: Malignant endocrine neoplasm
  DISAT1Z9: Advanced cancer
  DIS4X92K: Malignant tumor of parathyroid gland
• Disease Identifiers:
  MONDO ID: MONDO_0021311
  UMLS CUI: C0153653
  MedGen ID: 102283
  SNOMED CT ID: 363481002

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PTMS	OT9PS4Q0	Limited	Biomarker	[1]
THRAP3	OTG25JOG	Limited	Genetic Variation	[2]
CDC73	OT6JASZ1	Strong	Biomarker	[2]
EIF4EBP3	OTYY2WS5	Strong	Biomarker	[3]

References

• [1] MANAGEMENT OF ENDOCRINE DISEASE: Unmet therapeutic, educational and scientific needs in parathyroid disorders.Eur J Endocrinol. 2019 Sep 1;181(3):P1-P19. doi: 10.1530/EJE-19-0316. Epub 2019 Jun 1.
• [2] Complete genomic landscape of a recurring sporadic parathyroid carcinoma.J Pathol. 2013 Jul;230(3):249-60. doi: 10.1002/path.4203.
• [3] The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome.Cell Death Dis. 2012 Feb 2;3(2):266. doi: 10.1038/cddis.2012.6.