Details of Disease | DrugMAP

General Information of Disease (ID: DIS5AOLK)

Disease Name	Sick sinus syndrome
Synonyms	sinus node infection; SSS
Definition	A constellation of signs and symptoms which may include syncope, fatigue, dizziness, and alternating periods of bradycardia and atrial tachycardia, which is caused by sinoatrial node dysfunction.
Disease Hierarchy	DISYJI6J: Sinoatrial node disorder DIS6SVEE: Syndromic disease DIS5AOLK: Sick sinus syndrome
Disease Identifiers	MONDO ID MONDO_0001823 MESH ID D012804 UMLS CUI C0037052 MedGen ID 20749 HPO ID HP:0011704 SNOMED CT ID 36083008

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 8 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HCN4	TTQP04A	Limited	Altered Expression	[1]
SCN5A	TTZOVE0	Limited	Genetic Variation	[2]
CACNA1C	TTZIFHC	Strong	Genetic Variation	[3]
CACNA1D	TT7RGTM	Strong	Biomarker	[4]
HCN1	TTNB6UQ	Strong	Biomarker	[5]
KCNJ5	TTEO25X	Strong	Therapeutic	[4]
POMC	TT21AKM	Strong	Altered Expression	[6]
SCN10A	TT90XZ8	Strong	Genetic Variation	[7]
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⏷ Show the Full List of 8 DTT(s)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MYH6	OT3YNCH1	Strong	Genetic Variation	[8]
TBX18	OT3BEBLN	Strong	Biomarker	[9]
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References

1	Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.J Mol Cell Cardiol. 2020 Jan;138:291-303. doi: 10.1016/j.yjmcc.2019.10.009. Epub 2019 Nov 18.
2	Sex-Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome.J Am Heart Assoc. 2018 Sep 18;7(18):e009387. doi: 10.1161/JAHA.118.009387.
3	Genetic analysis of sick sinus syndrome in a family harboring compound CACNA1C and TTN mutations.Mol Med Rep. 2018 May;17(5):7073-7080. doi: 10.3892/mmr.2018.8773. Epub 2018 Mar 16.
4	G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41. doi: 10.1073/pnas.1517181113. Epub 2016 Feb 1.
5	Muscle weakness and impaired motor coordination in hyperpolarization-activated cyclic nucleotide-gated potassium channel 1-deficient rats.Exp Anim. 2020 Jan 29;69(1):11-17. doi: 10.1538/expanim.19-0067. Epub 2019 Jul 9.
6	Sick sinus syndrome associated with anti-programmed cell death-1.J Immunother Cancer. 2018 Jul 16;6(1):72. doi: 10.1186/s40425-018-0388-9.
7	Polymorphisms of the SCN10A Gene in Patients With Sick Sinus Syndrome.Kardiologiia. 2018 Nov 18;58(4):53-59. doi: 10.18087/cardio.2018.4.10096.
8	Novel mutation in the -myosin heavy chain gene is associated with sick sinus syndrome.Circ Arrhythm Electrophysiol. 2015 Apr;8(2):400-8. doi: 10.1161/CIRCEP.114.002534. Epub 2015 Feb 25.
9	TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome.J Physiol. 2018 Dec;596(24):6141-6155. doi: 10.1113/JP276508. Epub 2018 Oct 13.