Details of Disease | DrugMAP

General Information of Disease (ID: DIS5Z2HI)

Disease Name	Tumor of uterus
Synonyms	uterus neoplasm (disease); tumour of the uterus; uterine neoplasm; uterine tumour; uterus tumor; neoplasm of uterus; tumor of uterus; uterine tumor; neoplasm of the uterus; uterine neoplasms; tumor of the uterus; uterus tumour; uterus neoplasm
Definition	A neoplasm (disease) that involves the uterus.
Disease Hierarchy	DISGV2SE: Uterine disorder DISTBY9Z: Tumour DISDVNRY: Female reproductive system neoplasm DIS5Z2HI: Tumor of uterus
Disease Identifiers	MONDO ID MONDO_0021353 MESH ID D014594 UMLS CUI C0042138 MedGen ID 12030 HPO ID HP:0010784 SNOMED CT ID 126908007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GRPR	TTC1MVT	Limited	Altered Expression	[1]
CDKN1B	TTLGFVW	Strong	Biomarker	[2]
CTCFL	TTY0RZT	Strong	Altered Expression	[3]
HMGA1	TTBA219	Strong	Biomarker	[4]
PROM1	TTXMZ81	Strong	Biomarker	[5]
INHBA	TTVB30D	Definitive	Biomarker	[6]
SMAD3	TTHQZV7	Definitive	Biomarker	[6]
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⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
HOXB9	OTMVHQOU	Strong	Biomarker	[7]
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References

1	Gastrin-releasing peptide receptors in normal and neoplastic human uterus: involvement of multiple tissue compartments.J Clin Endocrinol Metab. 2005 Aug;90(8):4722-9. doi: 10.1210/jc.2005-0964. Epub 2005 Jun 7.
2	A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.Genes Dev. 2006 Jan 1;20(1):47-64. doi: 10.1101/gad.1384406.
3	Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression.Clin Cancer Res. 2007 Mar 15;13(6):1713-9. doi: 10.1158/1078-0432.CCR-05-2569.
4	Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts.Mol Cancer Ther. 2008 Jul;7(7):2090-5. doi: 10.1158/1535-7163.MCT-07-2282.
5	CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Mllerian tumor). Stem Cells. 2011 Oct;29(10):1485-95. doi: 10.1002/stem.711.
6	A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
7	Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo. Gene. 2016 Sep 30;590(2):234-43. doi: 10.1016/j.gene.2016.05.009. Epub 2016 May 13.