Details of Disease

General Information of Disease (ID: DIS66YLV)

• Disease Name: Acute adrenal insufficiency
• Synonyms: adrenocortical crisis; adrenal crisis; acute adrenal failure; Addisonian crisis; acute adrenocortical insufficiency
• Definition: Acute adrenal insufficiency (AAI) is a rare but severe condition caused by a sudden defective production of adrenal steroids (cortisol and aldosterone). It represents an emergency, thus the rapid recognition and prompt therapy are critical for survival even before the diagnosis is made.
• Disease Hierarchy:
  DISBV50J: Acute disease
  DISNMBYU: Primary adrenal insufficiency
  DIS66YLV: Acute adrenal insufficiency
• Disease Identifiers:
  MONDO ID: MONDO_0019801
  UMLS CUI: C0151467
  MedGen ID: 56227
  Orphanet ID: 95409
  SNOMED CT ID: 24867002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Betamethasone	DMAHJEF	Approved	Small molecular drug	[1]
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[2]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[3]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[4]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[5]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[6]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
STAR	TTEI40H	moderate	Genetic Variation	[8]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AAAS	OTJT9T23	Limited	Genetic Variation	[9]

References

• [1] Betamethasone FDA Label
• [2] Cortisone acetate FDA Label
• [3] Dexamethasone FDA Label
• [4] Hydrocortisone FDA Label
• [5] Methylprednisolone FDA Label
• [6] Prednisolone FDA Label
• [7] Triamcinolone FDA Label
• [8] Polycystic ovaries and adrenal insufficiency in a young pubescent female with lipoid congenital adrenal hyperplasia due to splice mutation of the StAR gene: a case report and review of the literature.J Pediatr Endocrinol Metab. 2010 Dec;23(12):1225-31. doi: 10.1515/jpem.2010.196.
• [9] Triple A syndrome: 32 years experience of a single centre (1977-2008).Eur J Pediatr. 2010 Nov;169(11):1323-8. doi: 10.1007/s00431-010-1222-7. Epub 2010 May 25.