Details of Disease

General Information of Disease (ID: DIS6FOW8)

Disease Name	Hypokalemia
Synonyms	potassium deficiency disorder; hypopotassemia; hypokalemia
Disease Class	5C77: Hypo-kalaemia
Definition	Any disorder caused by an insufficient amount or availability of potassium, which generally manifests with myalgia, tetany, hypotension, polyuria, and polydipsia.\|Editor note: NCIT hypokalemia is a finding. We use potassium deficiency disorder for equivalence but this is listed as nutritional in NCIT
Disease Hierarchy	DISWD40R: Disease DISV96AT: Mineral metabolism disease DIS0W6QK: Nutritional disorder DIS6FOW8: Hypokalemia
ICD Code	ICD-11 ICD-11: 5C77 ICD-10 ICD-10: E87.6 ICD-9 ICD-9: 276.8 Expand ICD-11 '5C77 Expand ICD-10 'E87.6 Expand ICD-9 276.8
Disease Identifiers	MONDO ID MONDO_0003019 MESH ID D007008 UMLS CUI C1514284 MedGen ID 271346 HPO ID HP:0002900 SNOMED CT ID 43339004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Calcium Chloride	DMYVFR3	Approved	Small molecular drug	[1]
Potassium	DMR5YD0	Approved	Small molecular drug	[2]
Potassium Chloride	DMMTAJC	Approved	Small molecular drug	[3]
Potassium Citrate	DMRBUPA	Approved	Small molecular drug	[4]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
L-aspartic acid	DMWGPO6	Investigative	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AKR1B1	TTFBNVI	Limited	Biomarker	[5]
RHCG	TTN5MZ3	Limited	Biomarker	[6]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ATP12A	DT5NLZA	Limited	Biomarker	[7]
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References

1	Calcium Chloride FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070999.
4	Potassium Citrate FDA Label
5	Downregulation of renal TonEBP in hypokalemic rats.Am J Physiol Renal Physiol. 2007 Jul;293(1):F408-15. doi: 10.1152/ajprenal.00502.2006. Epub 2007 Apr 4.
6	Effect of hypokalemia on renal expression of the ammonia transporter family members, Rh B Glycoprotein and Rh C Glycoprotein, in the rat kidney.Am J Physiol Renal Physiol. 2011 Oct;301(4):F823-32. doi: 10.1152/ajprenal.00266.2011. Epub 2011 Jul 13.
7	Expression of HKalpha2 protein is increased selectively in renal medulla by chronic hypokalemia.Am J Physiol. 1998 Sep;275(3):F433-40. doi: 10.1152/ajprenal.1998.275.3.F433.