Details of Disease

General Information of Disease (ID: DIS6XDK0)

Disease Name Subacute cutaneous lupus erythematosus
Disease Class EB50-EB5Z: Cutaneous lupus erythematosus
Definition
Subacute cutaneous lupus erythematosus (SCLE) is a form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. SCLE is associated with anti-Ro/SSA antibodies and can be drug-induced.
Disease Hierarchy
DISOIX6L: Cutaneous lupus erythematosus
DISBV50J: Acute disease
DIS6XDK0: Subacute cutaneous lupus erythematosus
ICD Code
ICD-11
ICD-11: EB50
ICD-10
ICD-10: L93.1
Expand ICD-11
'EB50
Expand ICD-10
'L93.1
Disease Identifiers
MONDO ID
MONDO_0015573
MESH ID
D008178
UMLS CUI
C0024140
MedGen ID
7403
Orphanet ID
163525
SNOMED CT ID
239891002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
KPP203 DM4WHOS Phase 2 NA [1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 10 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
TRIM21 OTA4UJCF moderate Biomarker [2]
C1QA OT6XKVVA Strong Genetic Variation [3]
C4A OTXMOYXU Strong Genetic Variation [4]
MBD1 OTD19VO6 Strong Altered Expression [5]
MBD3 OTRL76H5 Strong Altered Expression [5]
MBD4 OTWR9YXE Strong Altered Expression [5]
MPP1 OTA2ENZQ Strong Biomarker [6]
POLG2 OTDBMZJB Strong Biomarker [6]
PSMD12 OTWICA51 Strong Biomarker [6]
SSB OTCCTPBR Strong Biomarker [7]
------------------------------------------------------------------------------------
⏷ Show the Full List of 10 DOT(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Pathogenesis of subacute cutaneous lupus erythematosus.J Eur Acad Dermatol Venereol. 2008 Nov;22(11):1281-9. doi: 10.1111/j.1468-3083.2008.02806.x. Epub 2008 Jun 6.
3 Homozygous single nucleotide polymorphism of the complement C1QA gene is associated with decreased levels of C1q in patients with subacute cutaneous lupus erythematosus.Lupus. 2003;12(2):124-32. doi: 10.1191/0961203303lu329oa.
4 Clinical expression of systemic lupus erythematosus in patients with C4A deficiency.Medicine (Baltimore). 1993 Jul;72(4):236-44. doi: 10.1097/00005792-199307000-00003.
5 Abnormal DNA methylation in T cells from patients with subacute cutaneous lupus erythematosus.Br J Dermatol. 2008 Sep;159(4):827-33. doi: 10.1111/j.1365-2133.2008.08758.x. Epub 2008 Jul 17.
6 Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies.Arthritis Rheum. 1992 Dec;35(12):1483-91. doi: 10.1002/art.1780351212.
7 Clinical relevance of antibodies to Ro/SS-A and La/SS-B in subacute cutaneous lupus erythematosus and related conditions.Immunol Invest. 1993 Apr;22(3):189-203. doi: 10.3109/08820139309063402.