Details of Disease

General Information of Disease (ID: DIS6ZZMF)

• Disease Name: Vascular purpura
• Synonyms: vascular purpura; purpura, Schonlein-Henoch; Henoch Schonlein purpura; Henoch-Scholein purpura; purpura rheumatica; IgA vasculitis; Schoenlein-Henoch purpura; autoimmune purpura; HSP; purpura, autoimmune; Henoch-Schoenlein purpura; rheumatoid purpura; anaphylactoid purpura; allergic purpura; Henoch-Schonlein purpura
• Disease Class: 3B60: Non-thrombocytopenic purpura
• Definition: A systemic IgA vasculitis that affects small vessels. It is characterized by skin purpura, arthritis, and abdominal and/or renal involvement.
• Disease Hierarchy:
  DISL61M8: Necrotizing vasculitis
  DISI1ZGQ: Hypersensitivity vasculitis
  DISWMOW2: Immune complex mediated vasculitis
  DIS6ZZMF: Vascular purpura
• ICD Code:
  ICD-11: ICD-11: 3B60
  ICD-10: ICD-10: D69, D69.2
• Disease Identifiers:
  MONDO ID: MONDO_0019167
  MESH ID: D011695
  UMLS CUI: C0034152
  MedGen ID: 48265
  Orphanet ID: 761
  SNOMED CT ID: 191306005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Hesperidin	DMI5DW1	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 16 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
C3	TTJGY7A	Limited	Biomarker	[2]
PLAU	TTGY7WI	Limited	Therapeutic	[3]
ASIC2	TTVMWLP	Strong	Altered Expression	[4]
ASIC3	TTLGDIS	Strong	Biomarker	[4]
ATP1A1	TTWK8D0	Strong	Genetic Variation	[5]
ATXN3	TT6A17J	Strong	Biomarker	[6]
CAPN1	TT1WBIJ	Strong	Biomarker	[7]
DNAJB1	TTPXAWS	Strong	Biomarker	[8]
DNM2	TTVRA5G	Strong	Genetic Variation	[9]
ITPR1	TT5HWAT	Strong	Genetic Variation	[10]
KCNA2	TTVFB0O	Strong	Genetic Variation	[11]
NAAA	TTMN4HY	Strong	Biomarker	[12]
PNPLA6	TTWAQU2	Strong	Biomarker	[13]
RNF6	TT4S09X	Strong	Genetic Variation	[14]
SLC33A1	TTL69WB	Strong	Genetic Variation	[15]
VCP	TTHNLSB	Strong	Genetic Variation	[16]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP7B1	DE36TMY	Strong	Genetic Variation	[17]
FARS2	DE0WGR8	Strong	Genetic Variation	[18]

This Disease Is Related to 53 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AP4M1	OT2BG2Z3	moderate	Genetic Variation	[19]
AFG3L2	OTRPMAUX	Strong	Biomarker	[20]
ALDH18A1	OT6W40XU	Strong	Biomarker	[21]
ALS2	OT8BAM04	Strong	Genetic Variation	[22]
AP4B1	OTGJUIRA	Strong	Biomarker	[23]
ARHGEF5	OTUVGFT9	Strong	Altered Expression	[24]
ARL6IP1	OT536XAV	Strong	Genetic Variation	[25]
ATAD3A	OTWF6HBP	Strong	Genetic Variation	[26]
ATP13A2	OTKWBUGK	Strong	Genetic Variation	[27]
B4GALNT1	OTCY80HS	Strong	Genetic Variation	[28]
BICD2	OTVJ03NZ	Strong	Genetic Variation	[29]
C1GALT1	OT2ZSZ6P	Strong	Genetic Variation	[30]
CPT1C	OT8F1MBF	Strong	Biomarker	[31]
CYP2U1	OT6RXLXS	Strong	Genetic Variation	[32]
DDHD1	OTWTHOWK	Strong	Biomarker	[33]
DDHD2	OTUP0WHF	Strong	Biomarker	[34]
DPY30	OTLHCJ6C	Strong	Altered Expression	[35]
ERLIN2	OT551BVG	Strong	Genetic Variation	[10]
FA2H	OT8HA13U	Strong	Biomarker	[36]
FAT2	OTRGT3E8	Strong	Biomarker	[31]
GBA2	OTOZXG5D	Strong	Biomarker	[37]
HAVCR1	OT184CRZ	Strong	Altered Expression	[38]
IGFALS	OTTWCZYM	Strong	Biomarker	[39]
KIF13B	OTAFS1YV	Strong	Biomarker	[40]
KIF1A	OT3JVEGV	Strong	Biomarker	[41]
KIF1B	OTI1XQTO	Strong	Biomarker	[42]
KIF1C	OTKYLP1Q	Strong	Genetic Variation	[43]
KIF5B	OTT34MT8	Strong	Genetic Variation	[44]
KIF5C	OT35570Y	Strong	Genetic Variation	[44]
KRT10	OTSVRD3Q	Strong	Biomarker	[45]
MAD2L1BP	OT2O2IUJ	Strong	Biomarker	[42]
MGAT5	OTU4DD4G	Strong	Biomarker	[46]
MMP26	OT9O89KU	Strong	Altered Expression	[47]
NIPA1	OT9ODC8X	Strong	Biomarker	[48]
PAX2	OTKP1N8F	Strong	Genetic Variation	[49]
PITPNM3	OTHLZY8D	Strong	Genetic Variation	[50]
PLA2G6	OT5FL0WU	Strong	Genetic Variation	[51]
PLD3	OTL07SP2	Strong	Biomarker	[31]
POU2F3	OTIOOJWD	Strong	Genetic Variation	[52]
REEP1	OTEMVFX7	Strong	Biomarker	[53]
RNF170	OT2O6F4D	Strong	Genetic Variation	[10]
SCYL1	OTQ0IN7P	Strong	Biomarker	[31]
SEC24D	OTXR3KC9	Strong	Genetic Variation	[54]
SFXN1	OTL66767	Strong	Genetic Variation	[55]
SPART	OTIVOS2I	Strong	Genetic Variation	[56]
SPAST	OTIF3AJI	Strong	Biomarker	[57]
SPG11	OTZ7LJX4	Strong	Genetic Variation	[58]
SPTAN1	OT6VY3A3	Strong	Genetic Variation	[59]
TECPR2	OT1UFECZ	Strong	Biomarker	[54]
TFG	OT2KJENI	Strong	Biomarker	[60]
TIMELESS	OTD8DCBJ	Strong	Altered Expression	[24]
COL4A5	OTHG60RE	Definitive	Biomarker	[61]
REEP2	OTPCRA5O	Definitive	Genetic Variation	[62]

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