Details of Disease

Disease Name

Fibromatosis

fibromatosis

Definition

A poorly circumscribed neoplasm arising from the soft tissues. It is characterized by the presence of spindle-shaped fibroblasts and an infiltrative growth pattern.

Disease Hierarchy

:

DIS7535C: Fibromatosis

Disease Identifiers

MONDO ID

MONDO_0005031

MESH ID

D005350

UMLS CUI

C0016048

MedGen ID

8836

SNOMED CT ID

19928005

General Information of Disease (ID: DIS7535C)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Hydroxyurea	DMOQVU9	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GRM1	TTVBPDM	Limited	Biomarker	[2]
ANTXR2	TTOD34I	Strong	Biomarker	[3]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ASTE1	OT4NF5HN	Limited	Genetic Variation	[4]
CHAMP1	OTBGWU86	Limited	Genetic Variation	[5]
MOV10L1	OTP978LK	Limited	Genetic Variation	[5]
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References

1	Hydroxyurea FDA Label
2	GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.Nat Genet. 2014 May;46(5):474-7. doi: 10.1038/ng.2927. Epub 2014 Mar 23.
3	Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003 Oct;73(4):957-66. doi: 10.1086/378781. Epub 2003 Sep 12.
4	Dupuytren's and Ledderhose Diseases in a Family with LMNA-Related Cardiomyopathy and a Novel Variant in the ASTE1 Gene.Cells. 2017 Nov 1;6(4):40. doi: 10.3390/cells6040040.
5	Cytogenetic, clinical, and morphologic correlations in 78 cases of fibromatosis: a report from the CHAMP Study Group. CHromosomes And Morphology.Mod Pathol. 2000 Oct;13(10):1080-5. doi: 10.1038/modpathol.3880200.