Details of Disease

Disease Name

Asperger syndrome

asperger syndrome, susceptibility to; ASPG; autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional language

Definition

A disorder most often diagnosed in the pediatric years in which the individual displays marked impairment in social interaction and a repetitive, stereotyped pattern of behavior. The individual, however, displays no delay in language or cognitive development, which differentiates Asperger Syndrome from autism.|The name Aspergers is controversial, however, it seems to be the community accepted name.

Disease Hierarchy

DISXK8NV: Autism spectrum disorder

DIS7IBSP: Asperger syndrome

Disease Identifiers

MONDO ID

MONDO_0005259

MESH ID

D020817

UMLS CUI

C0236792

MedGen ID

68633

Orphanet ID

1162

SNOMED CT ID

23560001

General Information of Disease (ID: DIS7IBSP)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Memantine	DMD9WSC	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SLC6A4	TT3ROYC	Limited	Biomarker	[2]
VIP	TTGTWLF	Limited	Biomarker	[3]
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This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARSD	OTAHW9M8	Limited	Biomarker	[4]
NLN	OTFRITPU	moderate	Biomarker	[5]
NRXN1	OTJN1JQA	moderate	Genetic Variation	[6]
TSNAX	OTZ9SGWB	moderate	Genetic Variation	[7]
DISC1	OT43AW4H	Strong	Genetic Variation	[8]
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References

1	Memantine FDA Label
2	SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.Psychiatr Genet. 2008 Feb;18(1):31-9. doi: 10.1097/YPG.0b013e3282f08a06.
3	Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing.Am J Hum Genet. 2013 Aug 8;93(2):249-63. doi: 10.1016/j.ajhg.2013.06.012. Epub 2013 Jul 11.
4	Changes in Autism Nosology: The Social Impact of the Removal of Asperger's Disorder from the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5).J Autism Dev Disord. 2020 Sep;50(9):3358-3366. doi: 10.1007/s10803-019-04233-4.
5	Functional and structural asymmetry in primary motor cortex in Asperger syndrome: a navigated TMS and imaging study.Brain Topogr. 2019 May;32(3):504-518. doi: 10.1007/s10548-019-00704-0. Epub 2019 Apr 4.
6	A synaptic trek to autism.Curr Opin Neurobiol. 2009 Apr;19(2):231-4. doi: 10.1016/j.conb.2009.06.003. Epub 2009 Jun 21.
7	Association of DISC1 with autism and Asperger syndrome.Mol Psychiatry. 2008 Feb;13(2):187-96. doi: 10.1038/sj.mp.4002031. Epub 2007 Jun 19.
8	Limited association between Disrupted in Schizophrenia 1 (DISC1) gene and bipolar disorder in the Chinese population.Psychiatr Genet. 2011 Feb;21(1):42-6. doi: 10.1097/ypg.0b013e32834135d2.