Details of Disease

General Information of Disease (ID: DIS850J4)

Disease Name Pancreatic cancer, susceptibility to, 2
Synonyms
Pnca2; susceptibility to pancreatic cancer 2; pancreatic cancer 2; BRCA2 familial pancreatic carcinoma; pancreatic cancer, susceptibility to, 2; familial pancreatic carcinoma caused by mutation in BRCA2; pancreatic cancer, susceptibility to, type 2
Definition Any familial pancreatic carcinoma in which the cause of the disease is a mutation in the BRCA2 gene.
Disease Hierarchy
DISGXLG5: Hereditary neoplastic syndrome
DIS850J4: Pancreatic cancer, susceptibility to, 2
Disease Identifiers
MONDO ID
MONDO_0013235
UMLS CUI
C3150546
OMIM ID
613347
MedGen ID
461896

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
BRCA2 TTUARD6 Strong Autosomal dominant [1]
BRCA2 TTUARD6 Strong Biomarker [2]
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This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
BRCA2 OTF1XSV1 Strong Autosomal dominant [1]
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References

1 Current Approaches to Pancreatic Cancer Screening. Am J Pathol. 2019 Jan;189(1):22-35. doi: 10.1016/j.ajpath.2018.09.013.
2 ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.Genet Med. 2013 Jul;15(7):565-74. doi: 10.1038/gim.2013.73. Epub 2013 Jun 20.