Details of Disease | DrugMAP

General Information of Disease (ID: DIS8OAI7)

Disease Name	Continuous spikes and waves during sleep
Synonyms	continuous spikes and waves during slow-wave sleep; CSWSS syndrome; epileptic encephalopathy with continuous spike-and-wave during slow sleep; CSWS
Definition	Continuous spikes and waves during sleep (CSWS) is a rare epileptic encephalopathy of childhood characterized by seizures, an electroencephalographic (EEG) pattern of electrical status epilepticus in sleep (ESES) and neurocognitive regression in at least 2 domains of development.
Disease Hierarchy	DIS6IUH6: Landau-Kleffner syndrome DIS8OAI7: Continuous spikes and waves during sleep
Disease Identifiers	MONDO ID MONDO_0019123 UMLS CUI C5552731 MedGen ID 1790601

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GRIN2A	TTKJEMQ	Supportive	Autosomal dominant	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GRIN2A	OTTP0KN8	Supportive	Autosomal dominant	[1]
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References

1	GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction. Nat Genet. 2013 Sep;45(9):1061-6. doi: 10.1038/ng.2726. Epub 2013 Aug 11.