Details of Disease

General Information of Disease (ID: DIS8YN8N)

Disease Name	Corneal ulcer
Synonyms	ulcer disease of cornea; Ulcer, corneal; cornea ulcer disease
Disease Class	9A76-9A78: Corneal disease
Definition	Area of epithelial tissue loss from corneal surface; associated with inflammatory cells in the cornea and anterior chamber.
Disease Hierarchy	DISMFOEI: Keratitis DISHF2X6: Ulcer DIS8YN8N: Corneal ulcer
ICD Code	ICD-11 ICD-11: 9A76 ICD-10 ICD-10: H16.0 ICD-9 ICD-9: 370 Expand ICD-11 '9A76 Expand ICD-10 'H16.0 Expand ICD-9 370
Disease Identifiers	MONDO ID MONDO_0004577 MESH ID D003320 UMLS CUI C0010043 MedGen ID 40486 HPO ID HP:0012804 SNOMED CT ID 91514001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[1]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[2]
Dromostanolone	DMF2JDG	Approved	Small molecular drug	[3]
Fluorometholone	DM2HKC4	Approved	Small molecular drug	[4]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[5]
Medrysone	DMJ90O5	Approved	Small molecular drug	[6]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[7]
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⏷ Show the Full List of 7 Drug(s)

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GM6001	DM7V9CT	Discontinued in Phase 2	Small molecular drug	[8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SERPINF1	TTR59S1	moderate	Therapeutic	[9]
GSN	TTUH7OM	Strong	Biomarker	[10]
NGF	TTDN3LF	Strong	Biomarker	[11]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AMT	OTQYEWZQ	Strong	Biomarker	[12]
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References

1	Cortisone acetate FDA Label
2	Dexamethasone FDA Label
3	Dromostanolone FDA Label
4	Fluorometholone FDA Label
5	Hydrocortisone FDA Label
6	Medrysone FDA Label
7	Prednisolone FDA Label
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001387)
9	Pigment epithelium-derived factor (PEDF) attenuated capsaicin-induced neurotrophic keratouveitis.Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5173-80. doi: 10.1167/iovs.08-1852. Epub 2009 Jun 24.
10	Gelsolin amyloidosis as a cause of early aging and progressive bilateral facial paralysis.Plast Reconstr Surg. 2011 Jun;127(6):2342-2351. doi: 10.1097/PRS.0b013e318213a0a2.
11	The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony-Forming Efficiency, and the Limbal Stem Cell Phenotype.Stem Cells. 2019 Jan;37(1):139-149. doi: 10.1002/stem.2921.
12	Full-thickness conjunctival flap covering surgery combined with amniotic membrane transplantation for severe fungal keratitis.Exp Ther Med. 2018 Mar;15(3):2711-2718. doi: 10.3892/etm.2018.5765. Epub 2018 Jan 17.