Details of Disease | DrugMAP

General Information of Disease (ID: DIS95A0A)

Disease Name	Bone sarcoma
Synonyms	bone sarcoma; osseous sarcoma; sarcoma of the bone; skeletal sarcoma; sarcoma of bone
Definition	A sarcoma that arises from the bone. Representative examples are osteosarcoma and chondrosarcoma.
Disease Hierarchy	DIS38NA0: Bone cancer DISZDG3U: Sarcoma DIS95A0A: Bone sarcoma
Disease Identifiers	MONDO ID MONDO_0021054 UMLS CUI C1704327 MedGen ID 352831 Orphanet ID 223727 SNOMED CT ID 448710000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD248	TTYJWT7	Strong	Biomarker	[1]
DOT1L	TTSZ8T1	Strong	Biomarker	[2]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCNB3	OT5V72D3	Strong	Biomarker	[3]
H3-3B	OT9XHQ3C	Strong	Biomarker	[2]
HLA-DOA	OTZE5Q7R	Strong	Genetic Variation	[4]
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References

1	Endosialinexpressing bone sarcoma stemlike cells are highly tumorinitiating and invasive.Mol Med Rep. 2015 Oct;12(4):5665-70. doi: 10.3892/mmr.2015.4218. Epub 2015 Aug 12.
2	Genomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone.J Pathol. 2019 Feb;247(2):166-176. doi: 10.1002/path.5176. Epub 2018 Dec 27.
3	Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion.Histopathology. 2018 Jan;72(2):320-329. doi: 10.1111/his.13366. Epub 2017 Oct 30.
4	Associations between the cytotoxic T lymphocyte antigen 4 polymorphisms and risk of bone sarcomas.Tumour Biol. 2015 Jan;36(1):227-31. doi: 10.1007/s13277-014-2621-6. Epub 2014 Sep 18.